EP 1572642 A1 20050914 - 3-PYRROLYL UREA DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS
Title (en)
3-PYRROLYL UREA DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS
Title (de)
3-PYRROLYL-HARNSTOFF- DERIVATE UND IHRE VERWENDUNG ALS ANTIVIRALE MITTEL
Title (fr)
DERIVES D'UREE 3-PYRROLYLE ET LEUR UTILISATION EN TANT QU'AGENTS ANTIVIRAUX
Publication
Application
Priority
- DE 10257358 A 20021209
- EP 0313278 W 20031126
Abstract (en)
[origin: WO2004052852A1] The invention relates to substituted pyrroles of formula (I), in which: R<1> represents -OR<8> or -NR<9>R<10>; R<2> represents hydrogen, C1-C6 alkyl or aryl, whereby R<2> as an alkyl can be substituted with 0, 1, 2 or 3 substituents R<2-1 >independently of one another, selected from the group comprising halogen, hydroxy, C1-C6 alkoxy, hydroxycarbonyl, C1-C6 alkoxycarbonyl, C1-C6 alkylcarbonyloxy, amino, C1-C6 alkylamino, aminocarbonyl, C1-C6 alkylaminocarbonyl, C3-C8 cycloalkyl, a 5- to 10-membered heterocyclyl, C6-C10 aryl, phenoxy and a 5- to 10-membered heteroaryl and whereby R<2> as an aryl can be substituted with 0, 1, 2 or 3 substituents R<2-2> independently of one another, selected from the group comprising halogen, hydroxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, C1-C6 alkyl, C1-C6 alkoxy, hydroxycarbonyl, C1-C6 alkoxycarbonyl, amino, C1-C6 alkylamino, aminocarbonyl, C1-C6 alkylaminocarbonyl, C3-C8 cycloalkyl, a 5- to 10-membered heterocyclyl, C6-C10 aryl and a 5- to 10-membered heteroaryl; R<3> and R<4> independently of one another represent hydrogen or C1-C6 alkyl; R<5> and R<6> independently of one another represent hydrogen or C1-C6 alkyl; and R<7> represents a 3- to 12-membered carbocyclyl, whereby the carbocyclyl can be substituted with 0, 1, 2, 3, 4 or 5 substituents independently of one another, selected from the group comprising halogen, hydroxy, C1-C6 alkyl and C1-C6 alkoxy. The invention also relates to a method for producing said pyrroles, to their use for the treatment and/or prophylaxis of diseases, in addition to their use for producing medicaments for the treatment and/or prophylaxis of diseases, notably to their use as antiviral agents, in particular against cytomegaloviruses.
IPC 1-7
C07D 207/34; A61K 31/40; A61K 31/402; A61K 31/4025; C07D 401/06; C07D 401/12; C07D 403/06; C07D 403/12; C07D 405/12; C07D 413/06; C07D 405/06
IPC 8 full level
C07D 207/34 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 405/06 (2006.01); C07D 405/12 (2006.01); C07D 413/06 (2006.01)
CPC (source: EP)
A61P 31/12 (2017.12); C07D 207/34 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 405/06 (2013.01); C07D 405/12 (2013.01); C07D 413/06 (2013.01)
Citation (search report)
See references of WO 2004052852A1
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 2004052852 A1 20040624; AU 2003293723 A1 20040630; CA 2508788 A1 20040624; DE 10257358 A1 20040708; EP 1572642 A1 20050914
DOCDB simple family (application)
EP 0313278 W 20031126; AU 2003293723 A 20031126; CA 2508788 A 20031126; DE 10257358 A 20021209; EP 03789084 A 20031126