Global Patent Index - EP 1572746 A4

EP 1572746 A4 20060607 - HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)

Title (en)

HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)

Title (de)

HUMANE MONOKLONALE ANTIKÖRPER GEGEN DEN EPIDERMAL-GROWTH-FACTOR-REZEPTOR (EGFR)

Title (fr)

ANTICORPS MONOCLONAUX HUMAINS CONTRE LE RECEPTEUR DE FACTEUR DE CROISSANCE EPIDERMIQUE (EGFR)

Publication

EP 1572746 A4 20060607 (EN)

Application

EP 03808487 A 20031216

Priority

  • US 0340463 W 20031216
  • US 32009402 A 20021216

Abstract (en)

[origin: US9458236B2] Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

IPC 1-7

C07K 16/28; A61K 39/395

IPC 8 full level

C07K 16/28 (2006.01); A61K 39/00 (2006.01)

CPC (source: EP US)

A61K 39/3955 (2013.01 - US); A61K 45/06 (2013.01 - US); A61P 1/00 (2018.01 - EP); A61P 1/04 (2018.01 - EP); A61P 3/10 (2018.01 - EP); A61P 11/00 (2018.01 - EP); A61P 13/12 (2018.01 - EP); A61P 17/06 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 31/18 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61P 37/08 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 16/2863 (2013.01 - EP US); G01N 33/56966 (2013.01 - US); A01K 2217/05 (2013.01 - EP US); A01K 2217/075 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/21 (2013.01 - EP US); C07K 2317/73 (2013.01 - EP US); C07K 2317/732 (2013.01 - EP US); C07K 2317/76 (2013.01 - EP US); C07K 2317/92 (2013.01 - EP US)

Citation (search report)

  • [PXPY] WO 02100348 A2 20021219 - GENMAB AS [DK], et al
  • [Y] WO 0211677 A2 20020214 - IMCLONE SYSTEMS INC [US], et al
  • [Y] WO 0188138 A1 20011122 - SCANCELL LTD [GB], et al
  • [Y] MENDELSOHN J ET AL: "THE EGF RECEPTOR FAMILY AS TARGETS FOR CANCER THERAPY", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 19, no. 56, 2000, pages 6550 - 6565, XP001010397, ISSN: 0950-9232
  • [Y] YANG X-D ET AL: "Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy", CRITICAL REVIEWS IN ONCOLOGY / HEMATOLOGY, ELSEVIER SCIENCE IRELAND LTD., LIMERICK, IE, vol. 38, no. 1, April 2001 (2001-04-01), pages 17 - 23, XP002330089, ISSN: 1040-8428
  • [Y] "Genmabs HuMax-EGFr zerstŸrt Krebs-Tumore im Laborversuch mit Mäusen /", 13 June 2001 (2001-06-13), XP002307378, Retrieved from the Internet <URL:http://www.presseportal.de/story.htx?nr=256717&firmaid=17265> [retrieved on 20010613]
  • [Y] BASELGA J: "NEW THERAPEUTIC AGENTS TARGETING THE EPIDERMAL GROWTH FACTOR RECEPTOR", JOURNAL OF CLINICAL ONCOLOGY, GRUNE AND STRATTON, NEW YORK, NY, US, vol. 18, no. 21S, 1 November 2000 (2000-11-01), pages 54S - 59S, XP001031832, ISSN: 0732-183X
  • [Y] BUCHSBAUM DONALD J ET AL: "Treatment of pancreatic cancer xenografts with Erbitux (IMC-C225) anti-EGFR antibody, gemcitabine, and radiation.", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol. 54, no. 4, 15 November 2002 (2002-11-15), pages 1180 - 1193, XP002358776, ISSN: 0360-3016
  • [T] BLEEKER WIM K ET AL: "Dual mode of action of a human anti-epidermal growth factor receptor monoclonal antibody for cancer therapy", JOURNAL OF IMMUNOLOGY, vol. 173, no. 7, October 2004 (2004-10-01), pages 4699 - 4707, XP002358777, ISSN: 0022-1767
  • [A] FISHWILD DIANNE M ET AL: "High-avidity human IgG-kappa monoclonal antibodies from a novel strain of minilocus transgenic mice", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 14, no. 7, 1996, pages 845 - 851, XP002150461, ISSN: 1087-0156

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

US 2003194403 A1 20031016; US 7595378 B2 20090929; AT E531731 T1 20111115; AU 2003303237 A1 20040714; AU 2003303237 A8 20040714; EP 1572746 A2 20050914; EP 1572746 A4 20060607; EP 1572746 B1 20111102; JP 2006509828 A 20060323; JP 4606172 B2 20110105; US 2010008929 A1 20100114; US 2014141006 A1 20140522; US 8586041 B2 20131119; US 9458236 B2 20161004; WO 2004056847 A2 20040708; WO 2004056847 A3 20050616

DOCDB simple family (application)

US 32009402 A 20021216; AT 03808487 T 20031216; AU 2003303237 A 20031216; EP 03808487 A 20031216; JP 2004562284 A 20031216; US 0340463 W 20031216; US 201314055222 A 20131016; US 46405709 A 20090511