EP 1572891 A2 20050914 - BONE ANTI-RESORPTIVE COMPOUNDS
Title (en)
BONE ANTI-RESORPTIVE COMPOUNDS
Title (de)
ANTIRESORPTIONSVERBINDUNGEN DES KNOCHENS
Title (fr)
COMPOSES AGISSANT CONTRE LA RESORPTION OSSEUSE
Publication
Application
Priority
- US 0233047 W 20021015
- US 32936001 P 20011015
Abstract (en)
[origin: WO03033664A2] The present invention relates to polypeptides that bind to RANK and comprise amino acid sequences of RANKL external surface loops. The invention also relates to fragments, analogs, and derivatives of such polypeptides. The present invention further relates to compositions comprising the polypeptides described herein. Also included are methods for inhibiting osteoclast differentiation, methods for inhibiting bone resorption, and methods for competitively inhibiting RANKL activity. The invention also provides methods for treating diseases or conditions which are at least partially characterized by loss of bone mass.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 45/00 (2006.01); A61P 7/00 (2006.01); A61P 19/00 (2006.01); A61P 19/02 (2006.01); A61P 19/10 (2006.01); A61P 29/00 (2006.01); C07K 14/46 (2006.01); C07K 14/705 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12Q 1/42 (2006.01); C12Q 1/48 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61K 38/1709 (2013.01); A61P 7/00 (2017.12); A61P 19/00 (2017.12); A61P 19/02 (2017.12); A61P 19/10 (2017.12); A61P 29/00 (2017.12); C07K 14/70575 (2013.01); C07K 14/70578 (2013.01); C12Q 1/42 (2013.01); C12Q 1/485 (2013.01); G01N 33/6863 (2013.01); G01N 2500/10 (2013.01)
C-Set (source: EP)
Citation (search report)
See references of WO 03033664A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03033664 A2 20030424; WO 03033664 A9 20131107; CA 2463925 A1 20030424; CN 1635849 A 20050706; EP 1572891 A2 20050914; IL 161386 A0 20040927; JP 2005514919 A 20050526; MX PA04003527 A 20050620
DOCDB simple family (application)
US 0233047 W 20021015; CA 2463925 A 20021015; CN 02823125 A 20021015; EP 02782164 A 20021015; IL 16138602 A 20021015; JP 2003536394 A 20021015; MX PA04003527 A 20021015