EP 1575582 A4 20090311 - COMBINATION THERAPY FOR THE TREATMENT OF ACUTE LEUKEMIA AND MYELODYSPLASTIC SYNDROME
Title (en)
COMBINATION THERAPY FOR THE TREATMENT OF ACUTE LEUKEMIA AND MYELODYSPLASTIC SYNDROME
Title (de)
KOMBINATIONSTHERAPIE ZUR BEHANDLUNG VON AKUTER LEUKÄMIE UND MYELODYSPLASTISCHER SYNDROME
Title (fr)
THERAPIE COMBINEE DE TRAITEMENT DE LA LEUCEMIE AIGUE ET DU SYNDROME MYELODYSPLASIQUE
Publication
Application
Priority
US 0235532 W 20021106
Abstract (en)
[origin: WO2004043461A1] Methods of treatment and pharmaceutical combinations are provided for the treatment of acute leukemia, such as acute myelogenous leukemia, and myelodysplastic syndrome. The methods of treatment and pharmaceutical combinations employ an anti-CD33 cytotoxic conjugate in combination with at least one compound selected from the group consisting of an anthracycline and a pyrimidine or purine nucleoside analog. Preferred methods of treatment and pharmaceutical combinations employ gemtuzumab ozogamicin, daunorubicin, and cytarabine.
IPC 1-7
IPC 8 full level
A61K 31/44 (2006.01); A61K 31/445 (2006.01); A61K 31/53 (2006.01); A61K 31/70 (2006.01); A61K 45/06 (2006.01); E05F 3/00 (2006.01); E05F 3/10 (2006.01)
CPC (source: EP)
A61K 31/44 (2013.01); A61K 31/445 (2013.01); A61K 31/53 (2013.01); A61K 31/70 (2013.01); A61K 45/06 (2013.01); A61P 7/00 (2017.12); A61P 35/02 (2017.12); A61P 43/00 (2017.12); E05F 3/00 (2013.01); E05F 3/108 (2013.01)
Citation (search report)
- [A] WO 0212347 A1 20020214 - IMMUNOMEDICS INC [US], et al
- [A] AQUINO ET AL: "Acute myelogenous leukemia", CURRENT PROBLEMS IN PEDIATRICS, MOSBY, vol. 32, no. 2, 1 February 2002 (2002-02-01), pages 50 - 58, XP005008704, ISSN: 0045-9380
- [A] TRAIL P A ET AL: "Monoclonal antibody drug conjugates in the treatment of cancer", CURRENT OPINION IN IMMUNOLOGY, ELSEVIER, OXFORD, GB, vol. 11, no. 5, 1 October 1999 (1999-10-01), pages 584 - 588, XP004257589, ISSN: 0952-7915
- [A] ERIC L. SIEVERS: "Targeted therapy of acute myeloid leukemia with monoclonal antibodies and immunoconjugates", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 46, 2000, pages S18 - S22, XP002513083
- See references of WO 2004043461A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
Designated extension state (EPC)
LT LV MK RO SI
DOCDB simple family (publication)
WO 2004043461 A1 20040527; AU 2002348178 A1 20040603; AU 2010201113 A1 20100415; BR 0215935 A 20050809; CA 2504611 A1 20040527; CN 1720044 A 20060111; CR 7804 A 20081029; EP 1575582 A1 20050921; EP 1575582 A4 20090311; JP 2006508119 A 20060309; MX PA05004711 A 20050803; NO 20052009 D0 20050425; NO 20052009 L 20050627
DOCDB simple family (application)
US 0235532 W 20021106; AU 2002348178 A 20021106; AU 2010201113 A 20100322; BR 0215935 A 20021106; CA 2504611 A 20021106; CN 02830140 A 20021106; CR 7804 A 20050425; EP 02784400 A 20021106; JP 2004551359 A 20021106; MX PA05004711 A 20021106; NO 20052009 A 20050425