EP 1576003 A1 20050921 - PEPTIDES FOR PREVENTING, DIAGNOSING AND TREATING ANIMAL AND/OR HUMAN LEPTOSPIROSIS
Title (en)
PEPTIDES FOR PREVENTING, DIAGNOSING AND TREATING ANIMAL AND/OR HUMAN LEPTOSPIROSIS
Title (de)
PEPTIDE ZUR VORBEUGUNG, DIAGNOSE UND BEHANDLUNG DER LEPTOSPIROSE IM MENSCHEN ODER IM TIER
Title (fr)
PEPTIDES POUR LA PREVENTION, LE DIAGNOSTIC ET LE TRAITEMENT DE LA LEPTOSPIROSE ANIMALE ET/OU HUMAINE
Publication
Application
Priority
- FR 0303154 W 20031024
- FR 0213585 A 20021030
Abstract (en)
[origin: FR2846658A1] Compounds (I) that are the peptide of sequence (1), its homologs with at least 60% homology, or their salts, functional fragments, chemical analogs and chemical derivatives, are new. Compounds (I) that are the peptide of sequence (1), its homologs with at least 60% homology, and their salts, functional fragments, chemical analogs and chemical derivatives are new. Chemical analogs have one or more amino acids (aa) replaced by the D-enantiomer or a non-natural aa or one or more peptide bonds replaced by isosteres such as CH2NH, CH2S, CH2CH2, CH=CH, COCH2, CH(OH)CH2 or CH2SO. Chemical derivatives are des-alpha amino peptides; N-alpha-acyl substituted by RCO; derivatives substituted at C-terminal carboxy by amino, OR, SR or NHR; derivatives containing a pharmacophore, and polymers of the peptides. R = 1-50C alkyl, alkenyl, alkynyl, aryl or cyclic group. Independent claims are also included for: (1) peptides (II) of more than 100 aa that contain (I); (2) antibody (Ab) that recognizes (I) or (II), and its fragments or derivatives; (3) nucleic acid (III) that encodes (I) and (II); (4) vector that contains (III); (5) recombinant cell containing (III) or the vector of (4); (6) transgenic non-human organism that contains (III) in its cells; and (7) kit for detecting pathogenic strains of Leptospira in a biological sample or water that contains (III), as a probe or primer pair. Lys-Ala-Lys-Pro-Val-Gln-Lys-Leu-(Asp)5-Gly-Asp-Asp-Thr-Tyr-Lys-Glu-Glu-Arg-His-Asn-Lys (1)
IPC 1-7
IPC 8 full level
A61P 31/04 (2006.01); C07K 14/20 (2006.01); C07K 16/12 (2006.01); C12N 15/31 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP US)
A61P 31/04 (2018.01 - EP); C07K 14/20 (2013.01 - EP US); C07K 16/1207 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); A61K 39/00 (2013.01 - EP US); Y02A 50/30 (2018.01 - EP US); Y10S 530/825 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
FR 2846658 A1 20040507; FR 2846658 B1 20070330; AU 2003288330 A1 20040607; AU 2003288330 B2 20100513; EP 1576003 A1 20050921; US 2007197432 A1 20070823; US 7635480 B2 20091222; WO 2004041855 A1 20040521
DOCDB simple family (application)
FR 0213585 A 20021030; AU 2003288330 A 20031024; EP 03780234 A 20031024; FR 0303154 W 20031024; US 53319303 A 20031024