Global Patent Index - EP 1578365 A4

EP 1578365 A4 20090923 - MOLECULAR INTERACTIONS IN NEURONS

Title (en)

MOLECULAR INTERACTIONS IN NEURONS

Title (de)

MOLEKULARE INTERAKTIONEN IN NEURONEN

Title (fr)

INTERACTIONS MOLECULAIRES DANS DES NEURONES

Publication

EP 1578365 A4 20090923 (EN)

Application

EP 03768964 A 20031114

Priority

  • US 0336698 W 20031114
  • US 42621202 P 20021114
  • US 42621302 P 20021114

Abstract (en)

[origin: WO2004045535A2] Inhibitors that disrupt binding between a PDZ protein and cognate ligands such as N-methyl-D-aspartate (NMDA) receptors that are involved in various neurological disorders are provided. Pharmaceutical compositions containing such inhibitors and their use in treating neurological diseases such as stroke and ischemia are also disclosed. Screening methods to identify additional inhibitors of specific protein ligand interactions with PDZ proteins are also described.

IPC 1-7

A01N 37/18; A61K 38/00; A61K 38/04; A61K 38/06

IPC 8 full level

A61K 38/06 (2006.01); A61K 38/07 (2006.01); C07K 14/705 (2006.01); G01N 33/68 (2006.01)

CPC (source: EP)

A61K 38/06 (2013.01); A61K 38/07 (2013.01); G01N 33/6896 (2013.01)

Citation (search report)

  • [A] WO 0207751 A1 20020131 - AXCELL BIOSCIENCES CORP [US]
  • [X] CA 2273622 A1 20001202 - TYMIANSKI MICHAEL [CA]
  • [X] WO 02057413 A2 20020725 - UNIV LELAND STANFORD JUNIOR [US]
  • [XP] WO 03014303 A2 20030220 - ARBOR VITA CORP [US], et al
  • [XP] WO 02090981 A1 20021114 - JAPAN SCIENCE & TECH CORP [JP], et al
  • [YD] AARTS MICHELLE ET AL: "Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, WASHINGTON, DC, vol. 298, no. 5594, 25 October 2002 (2002-10-25), pages 846 - 850, XP002456870, ISSN: 0036-8075
  • [Y] ROUSSET R ET AL: "THE C-TERMINUS OF THE HTLV-1 TAX ONCOPROTEIN MEDIATES INTERACTION WITH THE PDZ DOMAIN OF CELLULAR PROTEINS", ONCOGENE, NATURE PUBLISHING GROUP, GB BASINGSTOKE, HANTS, vol. 16, no. 5, 5 February 1998 (1998-02-05), pages 643 - 654, XP000865909, ISSN: 0950-9232
  • [AD] KORNAU H-C ET AL: "Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, WASHINGTON, DC, vol. 269, no. 5231, 1 September 1995 (1995-09-01), pages 1737 - 1740, XP002196675, ISSN: 0036-8075
  • [A] LIM I A ET AL: "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, vol. 277, no. 24, 14 June 2002 (2002-06-14), pages 21697 - 21698, XP002991766, ISSN: 0021-9258 & EP 1391729 A1 20040225 - JAPAN SCIENCE & TECH CORP [JP]
  • See references of WO 2004045535A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2004045535 A2 20040603; WO 2004045535 A3 20060713; CA 2505479 A1 20040603; EP 1578365 A2 20050928; EP 1578365 A4 20090923

DOCDB simple family (application)

US 0336698 W 20031114; CA 2505479 A 20031114; EP 03768964 A 20031114