EP 1581507 A1 20051005 - BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR
Title (en)
BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR
Title (de)
BENZAMIDINHIBITOREN VON DEM P2X7 REZEPTOR
Title (fr)
INHIBITEURS BENZAMIDIQUES DU RECEPTEUR P2X7
Publication
Application
Priority
- IB 0306232 W 20031230
- US 43722802 P 20021231
Abstract (en)
[origin: WO2004058731A1] The present invention provides benzamide inhibitors of the P2X7 receptor of the formula (I) wherein R<1>-R<3> are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
IPC 1-7
C07D 249/12; C07D 233/70; A61K 31/4196; A61P 11/00; A61P 37/00
IPC 8 full level
A61P 11/00 (2006.01); A61P 37/00 (2006.01); C07D 233/70 (2006.01); C07D 249/12 (2006.01)
CPC (source: EP)
A61P 1/00 (2017.12); A61P 1/02 (2017.12); A61P 1/04 (2017.12); A61P 3/10 (2017.12); A61P 7/00 (2017.12); A61P 7/02 (2017.12); A61P 9/00 (2017.12); A61P 9/04 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 11/08 (2017.12); A61P 13/12 (2017.12); A61P 17/00 (2017.12); A61P 17/02 (2017.12); A61P 17/04 (2017.12); A61P 17/06 (2017.12); A61P 17/16 (2017.12); A61P 19/02 (2017.12); A61P 19/06 (2017.12); A61P 19/10 (2017.12); A61P 21/00 (2017.12); A61P 25/00 (2017.12); A61P 25/02 (2017.12); A61P 25/04 (2017.12); A61P 25/14 (2017.12); A61P 25/18 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 27/02 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); A61P 31/18 (2017.12); A61P 33/06 (2017.12); A61P 35/00 (2017.12); A61P 37/00 (2017.12); A61P 37/02 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C07D 233/70 (2013.01); C07D 249/12 (2013.01)
Citation (search report)
See references of WO 2004058731A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004058731 A1 20040715; AU 2003288640 A1 20040722; BR 0317844 A 20051206; CA 2511189 A1 20040715; EP 1581507 A1 20051005; JP 2006513205 A 20060420; MX PA05007130 A 20050826
DOCDB simple family (application)
IB 0306232 W 20031230; AU 2003288640 A 20031230; BR 0317844 A 20031230; CA 2511189 A 20031230; EP 03780483 A 20031230; JP 2004563508 A 20031230; MX PA05007130 A 20031230