EP 1587546 A2 20051026 - HYDROPHILIC CROSS-LINKING AGENTS FOR USE IN ENZYMATIC SENSORS
Title (en)
HYDROPHILIC CROSS-LINKING AGENTS FOR USE IN ENZYMATIC SENSORS
Title (de)
HYDROPHILE VERNETZUNGSMITTEL ZUR VERWENDUNG IN ENZYMATISCHEN SENSOREN
Title (fr)
AGENTS DE RETICULATION HYDROPHILES S'UTILISANT DANS DES CAPTEURS ENZYMATIQUES
Publication
Application
Priority
- US 0341060 W 20031219
- US 33550602 A 20021231
Abstract (en)
[origin: WO2004060297A2] An enzymatic sensor comprising an enzyme that generates a signal upon contact with an analyte; a substrate; and a cross-linking agent that comprises one or more hydrophilic moieties. The enzyme is immobilized in the substrate via the hydrophilic cross-linking agent. A biocompatible membrane, comprising the enzyme, substrate and the hydrophilic cross-linking agent, is applied to a sensor to produce an enzymatic sensor. The enzymatic sensor provides enhanced sensing capabilities by improving the diffusion of reactive species and thereby increasing the overall sensitivity and lifetime of the sensor. The incorporation of hydrophilic moieties into the cross-linking agent optimizes hydration of the sensor and creates hydrophilic channels or pathways for reactive species, such as H202 and the analyte of interest. The membrane and enzymatic sensor can be used in a method for detecting an analyte, such as glucose.
IPC 1-7
A61K 49/00; C12Q 1/26; C12N 1/00; C12N 11/18; C12N 9/96; C12N 9/02
IPC 8 full level
C12N 11/06 (2006.01); C12Q 1/00 (2006.01)
CPC (source: EP)
C12N 11/06 (2013.01); C12Q 1/006 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004060297 A2 20040722; WO 2004060297 A3 20050506; AU 2003297503 A1 20040729; AU 2003297503 A8 20040729; CA 2511549 A1 20040722; EP 1587546 A2 20051026; EP 1587546 A4 20070214
DOCDB simple family (application)
US 0341060 W 20031219; AU 2003297503 A 20031219; CA 2511549 A 20031219; EP 03814924 A 20031219