EP 1587943 A1 20051026 - METHOD FOR PREPARING A (R)- OR (S)- FORM OF N-(2,6-DIMETHYL PHENYL) ALANINE AND A COUNTER ENANTIOMERIC FORM OF N-(2,6-DIMETHYL PHENYL) ALANINE ESTER THERETO USING ENZYME
Title (en)
METHOD FOR PREPARING A (R)- OR (S)- FORM OF N-(2,6-DIMETHYL PHENYL) ALANINE AND A COUNTER ENANTIOMERIC FORM OF N-(2,6-DIMETHYL PHENYL) ALANINE ESTER THERETO USING ENZYME
Title (de)
VERFAHREN ZUR DARSTELLUNG DER (R)- ODER (S)-FORM VON N-(2,6-DIMETHYLPHENYL) ALANIN UND EINER ENANTIOMEREN GEGENFORM DES N-(2,6-DIMETHYLPHENYL)ALANINESTERS DAZU UNTER VERWENDUNG VON ENZYM
Title (fr)
METHODE DE PREPARATION D'UNE FORME A (R)- OU (S)- DE N-(2,6-DIMETHYL PHENYL) ALANINE ET D'UNE FORME CONTRE-ENANTIOMERE D'ESTER DE N-(2,6-DIMETHYL PHENYL) ALANINE S'Y RAPPORTANT UTILISANT UNE ENZYME
Publication
Application
Priority
- KR 0302673 W 20031205
- KR 20020081152 A 20021218
Abstract (en)
[origin: WO2004055195A1] The present invention provides methods for stereospecifically preparing (R)- or (S)-N-(2,6-dimethyl phenyl) alanine and counter ester compounds thereto using enzyme, which comprises reacting an enzyme having hydrolytic activity specific to one enantiomer of racemic (R), (S)-N-(2,6-dimethyl phenyl) alanine esters ((R)-enantiomer and (S)-enantiomer) with the racemic mixture above to obtain (R)- or (S)-N-(2,6-dimethyl phenyl) alanine by optical resolution, or extracting (S)- or (R)-N-(2,6-dimethyl phenyl) alanine ester as an unreacted compound from a reaction mixture using solvent, or esterifying a certain alanine enantiomer separated by the optical resolution with alcohol to synthesize (S)- or (R)-N-(2,6-dimethyl phenyl) alanine ester.
IPC 1-7
IPC 8 full level
C12P 13/06 (2006.01); C12P 41/00 (2006.01)
CPC (source: EP KR)
C12P 13/06 (2013.01 - EP); C12P 41/00 (2013.01 - KR); C12P 41/005 (2013.01 - EP)
Citation (search report)
See references of WO 2004055195A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004055195 A1 20040701; AU 2003303073 A1 20040709; EP 1587943 A1 20051026; JP 2006510364 A 20060330; KR 100654587 B1 20061207; KR 20040054842 A 20040626
DOCDB simple family (application)
KR 0302673 W 20031205; AU 2003303073 A 20031205; EP 03813309 A 20031205; JP 2004560677 A 20031205; KR 20020081152 A 20021218