EP 1588163 A2 20051026 - KINASES AND GPCRS INVOLVED IN APOPTOSIS
Title (en)
KINASES AND GPCRS INVOLVED IN APOPTOSIS
Title (de)
KINASEN UND G-PROTEIN GEKOPPELTE REZEPTOREN DIE IN DER APOPTOSE INVOLVIERT SIND
Title (fr)
KINASES ET RECEPTEURS GPCR IMPLIQUES DANS L'APOPTOSE
Publication
Application
Priority
- GB 2004000271 W 20040123
- GB 0301566 A 20030123
- US 45753303 P 20030325
Abstract (en)
[origin: WO2004065959A2] The present invention relates to a method of identifying an agent that modulates the function of an apoptosis-associated polypeptide having a sequence as set out in Table 1B, the method comprising: (a) providing a sample containing an apoptosis-associated polypeptide having a sequence as set out in Table 1B, and a candidate agent and incubating under conditions to permit binding of the candidate agent to the polypeptide; (b) measuring the binding of the apoptosis-associated polypeptide having a sequence as set out in Table 1B to the candidate agent in the sample; and (c) comparing the binding of the apoptosis-associated polypeptide having a sequence as set out in Table 1B to the candidate agent in the sample with the binding of the polypeptide having a sequence as set out in Table 1B to a control agent, wherein the control agent is known to not bind to the polypeptide having a sequence as set out in Table 1B; wherein an increase in the binding of the apoptosis-associated polypeptide having a sequence as set out in Table 1B to the candidate agent in the sample relative to the binding of the apoptosis-associated polypeptide having a sequence as set out in Table 1B to the control agent indicates that the candidate agent modulates the function of the apoptosis-associated polypeptide having a sequence as set out in Table 1B.
IPC 1-7
IPC 8 full level
G01N 33/50 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); G01N 33/5008 (2013.01); G01N 33/5011 (2013.01); G01N 33/5044 (2013.01); G01N 33/5088 (2013.01); G01N 33/5091 (2013.01); G01N 33/574 (2013.01); G01N 2510/00 (2013.01)
Citation (search report)
See references of WO 2004065959A2
Citation (examination)
- EP 1203958 A2 20020508 - SUMITOMO PHARMA [JP]
- UEHATA ET AL: "Caclcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension", NATURE, vol. 389, 30 October 1997 (1997-10-30), pages 990 - 994, XP002131752
- CHEVRIER ET AL: "The Rho-associated protein kinase p160ROCK is required for centrosome positioning", THE JOURNAL OF CELL BIOLOGY, vol. 157, no. 5, 28 May 2002 (2002-05-28), pages 807 - 817
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004065959 A2 20040805; WO 2004065959 A3 20041125; AU 2004205785 A1 20040805; AU 2004205785 A8 20040805; CA 2513148 A1 20040805; EP 1588163 A2 20051026; JP 2006518590 A 20060817
DOCDB simple family (application)
GB 2004000271 W 20040123; AU 2004205785 A 20040123; CA 2513148 A 20040123; EP 04704638 A 20040123; JP 2006500235 A 20040123