Global Patent Index - EP 1589980 A4

EP 1589980 A4 20070404 - METHODS OF DIAGNOSIS AND TREATMENT OF INTERSTITIAL LUNG DISEASE

Title (en)

METHODS OF DIAGNOSIS AND TREATMENT OF INTERSTITIAL LUNG DISEASE

Title (de)

VERFAHREN ZUR DIAGNOSE UND BEHANDLUNG VONINTERSTITIELLER LUNGENERKRANKUNG

Title (fr)

PROCEDES DE DIAGNOSTIC ET DE TRAITEMENT DE MALADIES PULMONAIRES INTERSTITIELLES

Publication

EP 1589980 A4 20070404 (EN)

Application

EP 03811670 A 20031209

Priority

  • US 0338915 W 20031209
  • US 43194902 P 20021209

Abstract (en)

[origin: WO2004056310A2] The present invention provides for a method of treating pulmonary disease in a subject comprising the administration to a subject in need of such treatment a therapeutically effective amount of a formulation comprising a SP-C therapeutic. Preferably, the SP-C therapeutic is an agent selected from the group consisting of an isolated SP-C protein, an isolated nucleic acid molecule encoding a SP-C protein, a SP-C receptor-specific antibody that stimulates the activity of the receptor, or pharmaceutically acceptable composition thereof. The present invention also provides methods of producing a mouse with a targeted disruption in a surfactant protein C (SP-C) gene. The present invention also provides for a transgenic mouse produced by a targeted disruption in a surfactant protein C (SP-C) gene. The present invention further provides for a cell or cell line from a transgenic mouse produced by a targeted disruption in a surfactant protein C (SP-C) gene.

IPC 8 full level

A01N 61/00 (2006.01); A01K 67/00 (2006.01); A61K 31/00 (2006.01); A61K 33/00 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61P 11/00 (2006.01); C07K 14/785 (2006.01); C12N 15/00 (2006.01); C12N 15/85 (2006.01); G01N 33/00 (2006.01)

CPC (source: EP)

A61K 38/1703 (2013.01); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 11/08 (2017.12); A61P 27/16 (2017.12); A61P 29/00 (2017.12); A61P 33/00 (2017.12); A61P 37/08 (2017.12); C07K 14/785 (2013.01); C12N 15/8509 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01)

Citation (search report)

  • [Y] WO 0180633 A2 20011101 - CHILDRENS HOSP MEDICAL CENTER [US], et al
  • [X] WO 0076535 A1 20001221 - BYK GULDEN LOMBERG CHEM FAB [DE], et al
  • [X] WO 0047623 A1 20000817 - CHIESI FARMA SPA [IT], et al
  • [X] US 6458759 B1 20021001 - EGAN EDMUND A [US], et al
  • [PY] US 2003221199 A1 20031127 - WHITSETT JEFFREY A [US]
  • [DXY] IKEGAMI MACHIKO ET AL: "Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury.", JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD. : 1985) FEB 2002, vol. 92, no. 2, February 2002 (2002-02-01), pages 519 - 526, XP002394843, ISSN: 8750-7587
  • [DXY] GLASSER S W ET AL: "Altered stability of pulmonary surfactant in SP-C-deficient mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 22 MAY 2001, vol. 98, no. 11, 22 May 2001 (2001-05-22), pages 6366 - 6371, XP002394842, ISSN: 0027-8424
  • [Y] SANFORD L P ET AL: "Influence of genetic background on knockout mouse phenotypes.", METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) 2001, vol. 158, 2001, pages 217 - 225, XP009071124, ISSN: 1064-3745
  • [DY] AMIN R S ET AL: "Surfactant protein deficiency in familial interstitial lung disease.", THE JOURNAL OF PEDIATRICS. JUL 2001, vol. 139, no. 1, July 2001 (2001-07-01), pages 85 - 92, XP002394844, ISSN: 0022-3476
  • [DY] THOMAS ALAN Q ET AL: "Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred.", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 1 MAY 2002, vol. 165, no. 9, 1 May 2002 (2002-05-01), pages 1322 - 1328, XP002394845, ISSN: 1073-449X
  • [DY] NOGEE LAWRENCE M ET AL: "Mutations in the surfactant protein C gene associated with interstitial lung disease.", CHEST. MAR 2002, vol. 121, no. 3 Suppl, March 2002 (2002-03-01), pages 20S - 21S, XP009070987, ISSN: 0012-3692
  • [PXY] GLASSER STEPHAN W ET AL: "Pneumonitis and emphysema in sp-C gene targeted mice.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 18 APR 2003, vol. 278, no. 16, 18 April 2003 (2003-04-18), pages 14291 - 14298, XP002394847, ISSN: 0021-9258
  • [X] DAVIS A J ET AL: "Lung function in premature lambs and rabbits treated with a recombinant SP-C surfactant.", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE FEB 1998, vol. 157, no. 2, February 1998 (1998-02-01), pages 553 - 559, XP002418346, ISSN: 1073-449X
  • [PX] HAFNER D ET AL: "CYCLOOXYGENASE-INHIBITION ENHANCES THE EFFECTS OF RSP-C SURFACTANT THERAPY IN A RAT LAVAGE MODEL OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS)", EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, JENA, DE, vol. 55, no. 1, July 2003 (2003-07-01), pages 59 - 68, XP009024125, ISSN: 0940-2993
  • See references of WO 2004056310A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2004056310 A2 20040708; WO 2004056310 A3 20050901; AU 2003302740 A1 20040714; BR 0317132 A 20051025; CA 2507613 A1 20040708; CN 100401896 C 20080716; CN 1731932 A 20060208; EP 1589980 A2 20051102; EP 1589980 A4 20070404; JP 2006519588 A 20060831

DOCDB simple family (application)

US 0338915 W 20031209; AU 2003302740 A 20031209; BR 0317132 A 20031209; CA 2507613 A 20031209; CN 200380107983 A 20031209; EP 03811670 A 20031209; JP 2004562253 A 20031209