EP 1590442 A2 20051102 - MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
Title (en)
MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
Title (de)
MAKROZYKLISCHE HEPATITIS-C-SERINPROTEASE-INHIBITOREN
Title (fr)
INHIBITEURS MACROCYCLIQUES DE LA SERINE PROTEASE DE L'HEPATITE C
Publication
Application
Priority
- US 2004003479 W 20040206
- US 36094703 A 20030207
- US 36585403 A 20030213
- US 38412003 A 20030307
Abstract (en)
[origin: WO2004072243A2] The present invention relates to compounds of Formula I, II or III, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: (I), (II), (III), wherein W is a substituted or unsubstituted heterocyclic ring system. The compounds inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
IPC 1-7
IPC 8 full level
A61K 38/05 (2006.01); A61K 31/407 (2006.01); A61K 31/41 (2006.01); A61K 31/435 (2006.01); A61K 31/501 (2006.01); A61K 38/06 (2006.01); A61K 38/12 (2006.01); A61P 31/14 (2006.01); C07D 487/04 (2006.01); C07D 513/04 (2006.01); C07K 5/02 (2006.01); C07K 5/08 (2006.01); C07K 5/083 (2006.01); C07K 5/12 (2006.01); C12N 1/00 (2006.01); A61K 38/00 (2006.01)
IPC 8 main group level
C12N (2006.01)
CPC (source: EP KR)
A61K 38/12 (2013.01 - KR); A61P 31/14 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 487/04 (2013.01 - EP); C07D 513/04 (2013.01 - EP); C07K 5/02 (2013.01 - EP); C07K 5/0806 (2013.01 - EP); C07K 5/12 (2013.01 - KR); A61K 38/00 (2013.01 - EP)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004072243 A2 20040826; WO 2004072243 A3 20051103; AU 2004211637 A1 20040826; AU 2004211637 B2 20090813; AU 2004211637 C1 20100819; CA 2515216 A1 20040826; CN 1771050 A 20060510; EP 1590442 A2 20051102; EP 1590442 A4 20070718; JP 2007524576 A 20070830; KR 100940619 B1 20100205; KR 20050111585 A 20051125
DOCDB simple family (application)
US 2004003479 W 20040206; AU 2004211637 A 20040206; CA 2515216 A 20040206; CN 200480009268 A 20040206; EP 04709020 A 20040206; JP 2006503381 A 20040206; KR 20057014600 A 20040206