EP 1590449 A2 20051102 - ICOS+ SUPPRESSER T CELLS
Title (en)
ICOS+ SUPPRESSER T CELLS
Title (de)
ICOS+ SUPPRESSER T CELLS
Title (fr)
LYMPHOCYTES T SUPPRESSEURS ICOS+
Publication
Application
Priority
- BE 2004000017 W 20040130
- GB 0302167 A 20030130
Abstract (en)
[origin: WO2004067697A2] Human antigen-presenting cells (APC), on which the costimulatory ligands CD40, CD80 and CD86 are blocked e.g. by antibodies, are unable to fully activate allogeneic T cells in vitro. Instead, they induce a long-lasting functional T cell alteration with lack of IL-2, IL-5 and IL-13 production upon allogeneic restimulation. Present invention demonstrates that despite costimulation blockade during in vitro allogeneic stimulation, a non-proliferating responder T cell subpopulation is activated to express ICOS. Removal of these ICOS-expressing cells restores the capacity of reciprocal ICOS negative cells to proliferate and to produce Th1 and Th2 cytokines after allogeneic restimulation. ICOS+ cells on the other hand are anergic at the level of proliferation and Th1 and Th2 cytokine production. However, these cells can produce IL-10, and they suppress the allogeneic responses of either primed or naive T cells through inhibition of IL-2 mRNA transcription. Suppression is not mediated by IL-10, but depends on cell-cell contact. Thus a subtype of regulatory T cells in human blood can be activated in the absence of costimulatory signals from CD40, CD80 and CD86, and that they can be identified by expression of ICOS after activation.
IPC 1-7
IPC 8 full level
C12N 5/0783 (2010.01); A61K 35/12 (2015.01)
CPC (source: EP)
A61K 39/4611 (2023.05); A61K 39/4621 (2023.05); A61K 39/46433 (2023.05); A61K 39/46434 (2023.05); C12N 5/0636 (2013.01); A61K 2035/122 (2013.01); A61K 2035/124 (2013.01); C12N 2501/51 (2013.01); C12N 2501/52 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004067697 A2 20040812; WO 2004067697 A3 20040916; WO 2004067697 B1 20041118; EP 1590449 A2 20051102; GB 0302167 D0 20030305
DOCDB simple family (application)
BE 2004000017 W 20040130; EP 04706580 A 20040130; GB 0302167 A 20030130