EP 1592431 A4 20070822 - METHOD OF MODULATING IL-6
Title (en)
METHOD OF MODULATING IL-6
Title (de)
VERFAHREN ZUR IL-6-MODULATION
Title (fr)
PROCEDE DE MODULATION DE IL-6
Publication
Application
Priority
- AU 2004000049 W 20040115
- AU 2003900194 A 20030115
Abstract (en)
[origin: WO2004062675A1] Use of a glycoalkaloid composition containing at least one Z Glycoalkaloid of formula I, wherein: either one or both of the dotted lines represents a double bond, and the other a single bond, or both represent single bonds; A: represents a radical selected from the radicals of general formulae (II) to (V); each of R<1> is a radical separately selected from the group consisting of hydrogen, amino, oxo and OR<4>; each of R<2> is a radical separately selected from the group consisting of hydrogen, amino and OR<4>; each of R<3> is a radical separately selected from the group consisting of hydrogen, carbohydrate and a carbohydrate; "X" is a radical selected from the group comprising -CH2-, -O- and -NH2-; and wherein the compound includes at least one R<4> group that is a carbohydrate or a derivative such as one selected from the group comprising glyceric aldehyde, glycerose, erythrose, threose, ribose, arabinose, xylose, lyxose, altrose, allose, gulose, mannose, glucose, idose, galactose, talose, rhamnose, dihydroxyactone, erythrulose, ribulose, xylulose, psicose, fructose, sorbose, tagatose, and other hexoses, heptoses, octoses, nanoses, decoses, deoxysugars with branched chains, (e.g. apiose, hamamelose, streptose, cordycepose, mycarose and cladinose), compounds wherein the aldehyde, ketone or hydroxyl groups have been substituted (e.g. N-acetyl, acetyl, methyl, replacement of CH2OH), sugar alcohols, sugar acids, benzimidazoles, the enol salts of the carbohydrates, saccharinic acids, sugar phosphates; as an IL-6 antagonist.
IPC 1-7
IPC 8 full level
A61K 31/58 (2006.01); A61K 31/704 (2006.01); A61K 31/7048 (2006.01); A61K 31/706 (2006.01); A61P 15/00 (2006.01); A61P 15/08 (2006.01); A61P 15/16 (2006.01); A61P 17/00 (2006.01); A61P 17/02 (2006.01); A61P 17/12 (2006.01); A61P 25/00 (2006.01); A61P 35/00 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61K 31/58 (2013.01); A61K 31/704 (2013.01); A61K 31/7048 (2013.01); A61K 31/706 (2013.01); A61P 15/00 (2017.12); A61P 15/08 (2017.12); A61P 15/16 (2017.12); A61P 17/00 (2017.12); A61P 17/02 (2017.12); A61P 17/12 (2017.12); A61P 25/00 (2017.12); A61P 35/00 (2017.12); G01N 33/5011 (2013.01); G01N 33/5038 (2013.01); G01N 33/6869 (2013.01); G01N 2500/00 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
- [A] US 5962477 A 19991005 - MAK VIVIEN [US]
- [X] EP 0020029 A1 19801210 - ARUBA PTY LTD [AU]
- [X] US 2002006931 A1 20020117 - BEACHY PHILIP A [US], et al
- [A] VILLUNGER A ET AL: "Constituents of autocrine IL-6 loops in myeloma cell lines and their targeting for suppression of neoplastic growth by antibody strategies.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER 8 FEB 1996, vol. 65, no. 4, 8 February 1996 (1996-02-08), pages 498 - 505, XP002421949, ISSN: 0020-7136
- See references of WO 2004062675A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004062675 A1 20040729; AU 2003900194 A0 20030130; CA 2516398 A1 20040729; EP 1592431 A1 20051109; EP 1592431 A4 20070822
DOCDB simple family (application)
AU 2004000049 W 20040115; AU 2003900194 A 20030115; CA 2516398 A 20040115; EP 04702261 A 20040115