Title (en)

SINGLE NUCLEOTIDE POLYMORPHISMS AS PREDICTIVE DIAGNOSTICS FOR ADVERSE DRUG REACTIONS (ADR) AND DRUG EFFICACY

Title (de)

EINZELNUKLEOTIDPOLYMORPHISMEN ALS PRÄDIKTIVE VORHERSAGE VON UNERWÜNSCHTEN MEDIKAMENTENREAKTIONEN UND MEDIKAMENTENWIRKSAMKEIT

Title (fr)

POLYMORPHISMES DE NUCLEOTIDE SIMPLE UTILISES EN TANT QUE DIAGNOSTICS PREDICTIFS D'EFFET INDESIRABLE (ADR) ET D'EFFICACITE D'UN MEDICAMENT

Publication

EP 1592808 A2 20051109 (EN)

Application

EP 04704556 A 20040123

Priority

• EP 2004000539 W 20040123
• EP 03002212 A 20030131
• EP 03002153 A 20030203
• EP 04704556 A 20040123

Abstract (en)

[origin: WO2004067774A2] The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes.

IPC 1-7

C12Q 1/68; G01N 33/50; C07K 14/47; C12N 15/63; A61K 48/00; A61K 38/17

IPC 8 full level

A61K 38/17 (2006.01); A61K 48/00 (2006.01); C07K 14/47 (2006.01); C12N 15/63 (2006.01); C12Q 1/68 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01)

CPC (source: EP)

C12Q 1/6883 (2013.01); G01N 33/5008 (2013.01); G01N 33/502 (2013.01); G01N 33/5091 (2013.01); G01N 33/6893 (2013.01); C12Q 2600/156 (2013.01); G01N 2800/52 (2013.01)

Citation (search report)

See references of WO 2004067774A2

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2004067774 A2 20040812; WO 2004067774 A3 20041021; EP 1592808 A2 20051109

DOCDB simple family (application)

EP 2004000539 W 20040123; EP 04704556 A 20040123