EP 1594841 A1 20051116 - VEGFR-2 AND VEGFR-3 INHIBITORY ANTHRANYLAMIDOPYRIDINES
Title (en)
VEGFR-2 AND VEGFR-3 INHIBITORY ANTHRANYLAMIDOPYRIDINES
Title (de)
VEGFR-2 UND VEGFR-3 INHIBITORISCHE ANTHRANYLAMIDPYRIDINE
Title (fr)
ANTHRANYLAMIDOPYRIMIDINES INHIBANT VEGFR-2 ET VEGFR-3
Publication
Application
Priority
- EP 0307964 W 20030722
- DE 10235690 A 20020731
- DE 10328036 A 20030619
Abstract (en)
[origin: WO2004013102A1] VEGFR-2 and VEGFR-3 inhibitory anthranylamidopyridinamides, the production and use thereof as medicaments for the treatment of diseases caused by persistent angiogenesis and intermediates for production of the compounds are disclosed. Said compounds can be used, for example, in tumour or metastasis growth, psoriasis, Kaposi's sarcoma, restenosis, such as for example, stent-induced restenoses, endometriosis, Crohn's disease, Hodgkin's disease, leukaemia, arthritis, such as rheumatoid arthritis, haemangioma, angiofibroma, eye disease, such as diabetic retinopathy, neovascular glaucoma, renal diseases, such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombic microangiopathic syndrome, transplant rejection and glomerulopathy, fibrotic diseases, such as liver cirrhosis, mesangial cell proliferative diseases, artherosclerosis, injuries to nervous tissue and inhibition of the reocclusion of vessels after balloon catheter treatment, in vessel prosthetics, or after the application of mechanical devices to hold open vessels, such as for example, stents, as immune suppressants, as a support for scar-free wound healing, age spots and contact dermatitis. Said compounds may also be used as VEGFR-3 inhibitors in lymphangiogenesis.
IPC 1-7
C07D 213/74; C07D 401/12; C07D 213/73; C07D 213/75; C07D 409/12; C07D 401/04; C07D 413/14; C07D 401/14; C07D 413/04; C07D 417/10; C07D 213/61; C07D 417/04; A61K 31/44; A61P 19/00; A61P 35/00
IPC 8 full level
A61K 31/44 (2006.01); A61K 31/4406 (2006.01); A61K 31/4436 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); A61K 31/553 (2006.01); A61P 1/04 (2006.01); A61P 1/16 (2006.01); A61P 3/10 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 9/14 (2006.01); A61P 13/12 (2006.01); A61P 15/00 (2006.01); A61P 17/00 (2006.01); A61P 17/06 (2006.01); A61P 19/00 (2006.01); A61P 19/02 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 27/06 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 35/04 (2006.01); A61P 37/02 (2006.01); C07D 213/61 (2006.01); C07D 213/73 (2006.01); C07D 213/74 (2006.01); C07D 213/75 (2006.01); C07D 213/76 (2006.01); C07D 213/82 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 413/04 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01)
CPC (source: EP KR)
A61P 1/04 (2017.12 - EP); A61P 1/16 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/08 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/14 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 15/08 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 27/06 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 35/04 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 213/61 (2013.01 - EP); C07D 213/73 (2013.01 - EP KR); C07D 213/74 (2013.01 - EP KR); C07D 213/75 (2013.01 - EP); C07D 401/04 (2013.01 - EP); C07D 401/12 (2013.01 - EP); C07D 401/14 (2013.01 - EP); C07D 409/12 (2013.01 - EP); C07D 413/04 (2013.01 - EP); C07D 413/14 (2013.01 - EP); C07D 417/04 (2013.01 - EP)
Citation (search report)
See references of WO 2004013102A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004013102 A1 20040212; AU 2003281855 A1 20040223; BR 0313122 A 20050705; CA 2493026 A1 20040212; CA 2493026 C 20110524; CN 1671666 A 20050921; CO 5720998 A2 20070131; CR 7673 A 20060529; EC SP055631 A 20050418; EP 1594841 A1 20051116; HR P20050187 A2 20051031; IL 166377 A0 20060116; JP 2005538112 A 20051215; JP 2011026344 A 20110210; JP 4777648 B2 20110921; KR 20050026535 A 20050315; MX PA04012948 A 20050912; NO 20051035 L 20050429; PL 374610 A1 20051031; RS 20050084 A 20070921; RU 2005105683 A 20060120
DOCDB simple family (application)
EP 0307964 W 20030722; AU 2003281855 A 20030722; BR 0313122 A 20030722; CA 2493026 A 20030722; CN 03818334 A 20030722; CO 05017954 A 20050225; CR 7673 A 20050203; EC SP055631 A 20050224; EP 03740470 A 20030722; HR P20050187 A 20050225; IL 16637705 A 20050120; JP 2004525272 A 20030722; JP 2010233026 A 20101015; KR 20057001611 A 20050128; MX PA04012948 A 20030722; NO 20051035 A 20050225; PL 37461003 A 20030722; RU 2005105683 A 20030722; YU P20050084 A 20030722