Global Patent Index - EP 1595542 A1

EP 1595542 A1 20051116 - Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds

Title (en)

Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds

Title (de)

Transdermale iontophoretische Verabreichung von Piperazinyl-2(3H)-benzoxazolon-Verbindungen

Title (fr)

Administration iontophoretique de composés piperazinyl-2(3h)-benzoxazoloniques

Publication

EP 1595542 A1 20051116 (EN)

Application

EP 04101253 A 20040326

Priority

EP 04101253 A 20040326

Abstract (en)

The present invention is related to the use of a compound of the general formula <CHEM> wherein R is methyl, ethyl, ethyl substituted with one or more fluorine atoms, or cycloalkyl-(C3-C7)-methyl optionally substituted with one or more fluorine atoms or benzyl optionally substituted with a group selected from phenyl, furanyl and thienyl which groups are optionally substituted with 1-3 substituents from the group hydroxy, halogen, C1-4-alkoxy, C1-4-alkyl, cyano, aminocarbonyl, mono- or di-C1-4-alkylaminocarbonyl; and pharmaceutically acceptable salts and prodrugs thereof, for the manufacture of a composition for transdermal administration by iontophoresis.

IPC 1-7

A61K 31/496; A61P 25/16; A61P 25/14

IPC 8 full level

A61K 31/496 (2006.01); A61N 1/30 (2006.01); A61N 1/32 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01)

CPC (source: EP)

A61K 31/496 (2013.01); A61N 1/044 (2013.01); A61N 1/30 (2013.01); A61N 1/325 (2013.01); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61N 1/0436 (2013.01)

Citation (search report)

  • [XAY] EP 1336406 A1 20030820 - SOLVAY PHARM BV [NL]
  • [XAY] WO 0185168 A1 20011115 - SOLVAY PHARM BV [NL], et al
  • [XAY] US 2004013620 A1 20040122 - KLOSE KATHRYN TRACI-JANE [AU], et al
  • [DX] WO 0185725 A1 20011115 - SOLVAY PHARM BV [NL], et al
  • [DA] WO 0029397 A1 20000525 - DUPHAR INT RES [NL], et al
  • [X] WO 0136039 A2 20010525 - NOVARTIS AG [CH], et al
  • [X] US 5207752 A 19930504 - SORENSON PAUL D [US], et al
  • [X] WO 03035167 A2 20030501 - POWER PAPER LTD [IL], et al
  • [XY] OLBRICH R ET AL: "ANTIPARKINSONIAN ANTIDEPRESSANT ANXIOLYTIC DOPAMINE D2 PARTIAL AGONIST 5-HT 1A AGONIST 7-(4-METHYL-1-PIPERAZINYL)BENZOXAZOL-2(3H)-ONE MONOHYDROCHIORIDE AN EVALUATION OF THE PARTIAL DOPAMINE AGONIST TERGURIDE REGARDING POSITIVE SYMPTOMS REDUCTION IN SCH", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 26, no. 2, 2001, pages 128 - 132, XP001061489, ISSN: 0377-8282
  • [XAY] WOLF WILLIAM A: "SLV-308. Solvay.", CURRENT OPINION IN INVESTIGATIONAL DRUGS (LONDON, ENGLAND : 2000) JUL 2003, vol. 4, no. 7, July 2003 (2003-07-01), pages 878 - 882, XP008033520, ISSN: 1472-4472
  • [X] MCCREARY A C ET AL: "SLV308: A novel antiparkinsonian agent with antidepressant and anxiolytic efficacy", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, & 31ST ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; SAN DIEGO, CALIFORNIA, USA; NOVEMBER 10-15, 2001, pages 531, XP001197381, ISSN: 0190-5295
  • [XY] JOHNSTON L C ET AL: "THE NOVEL DOPAMINE D2 RECEPTOR PARTIAL AGONIST, SLV-308, REVERSES MOTOR DISABILITY IN MPTP-LESIONED COMMON MARMOSETS (CALLITHRIXJACCHUS)", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 133, no. SUPPL, May 2001 (2001-05-01), pages U - 70,AN134P, XP001061442, ISSN: 0007-1188
  • [A] FEENSTRA, R. W. ET AL: "New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D2-receptor and serotonin 5-HT1A-receptor affinities", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 11(17), 2345-2349 CODEN: BMCLE8; ISSN: 0960-894X, 2001, XP002290769

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

EP 1595542 A1 20051116; AR 048186 A1 20060405; AU 2005239833 A1 20051117; AU 2005239833 B2 20100225; BR PI0508848 A 20070828; CA 2558113 A1 20051117; CN 1938030 A 20070328; CN 1938030 B 20101020; EP 1742632 A2 20070117; HK 1098048 A1 20070713; JP 2007530512 A 20071101; RU 2006137714 A 20080510; RU 2371179 C2 20091027; SA 05260067 A 20051203; TW 200536839 A 20051116; UA 87493 C2 20090727; WO 2005107754 A2 20051117; WO 2005107754 A3 20051229

DOCDB simple family (application)

EP 04101253 A 20040326; AR P050101147 A 20050323; AU 2005239833 A 20050325; BR PI0508848 A 20050325; CA 2558113 A 20050325; CN 200580009878 A 20050325; EP 05768713 A 20050325; EP 2005051401 W 20050325; HK 07104262 A 20070424; JP 2007504423 A 20050325; RU 2006137714 A 20050325; SA 05260067 A 20050326; TW 94109105 A 20050324; UA A200611249 A 20050325