EP 1599214 A4 20060621 - METHODS AND COMPOSITIONS FOR TREATING CERVICAL CANCER
Title (en)
METHODS AND COMPOSITIONS FOR TREATING CERVICAL CANCER
Title (de)
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON GEBÄRMUTTERHALSKREBS
Title (fr)
METHODES ET COMPOSITIONS DESTINEES A TRAITER LE CANCER DU COL UTERIN
Publication
Application
Priority
- US 2004006001 W 20040227
- US 45046403 P 20030227
- US 49009403 P 20030725
- US 63059003 A 20030729
Abstract (en)
[origin: WO2004076646A2] The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid sequence of a particular PDZ domain from the cellular protein MAGI-1. The invention provides methods to treat diseases associated with expression of pathogen proteins by modulating their interactions with MAGI-1, and a number of isolated peptides useful in such methods. Also provided are kits for performing the subject methods.
IPC 1-7
A61K 38/00; C07K 17/00; C07K 4/00; C07K 4/02; C07K 5/00; C07K 7/00; C07K 9/00
IPC 8 full level
G01N 33/574 (2006.01)
CPC (source: EP)
G01N 33/57411 (2013.01); G01N 2333/025 (2013.01)
Citation (search report)
- [XY] WO 03014303 A2 20030220 - ARBOR VITA CORP [US], et al
- [XY] THOMAS MIRANDA ET AL: "Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation", ONCOGENE, vol. 21, no. 33, 1 August 2002 (2002-08-01), pages 5088 - 5096, XP002380805, ISSN: 0950-9232
- See references of WO 2004076646A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004076646 A2 20040910; WO 2004076646 A3 20050609; EP 1599214 A2 20051130; EP 1599214 A4 20060621
DOCDB simple family (application)
US 2004006001 W 20040227; EP 04715735 A 20040227