EP 1601696 A1 20051207 - COMPOSITIONS AND METHODS FOR INHIBITING INFLAMMATION OF VESSEL WALLS AND FORMATION OF NEOINTIMAL HYPERPLASIA
Title (en)
COMPOSITIONS AND METHODS FOR INHIBITING INFLAMMATION OF VESSEL WALLS AND FORMATION OF NEOINTIMAL HYPERPLASIA
Title (de)
ZUSAMMENSETZUNGEN UND METHODEN UM DIE ENTZÜNDUNG VON GEFÄSSWÄNDEN UND DIE BILDUNG VON NEOINTIMALER HYPERPLASIE ZU HEMMEN
Title (fr)
COMPOSITIONS ET PROCEDES PERMETTANT D'INHIBER L'INFLAMMATION DES PAROIS VASCULAIRES ET LA FORMATION D'HYPERPLASIE DE NEO-INTIMA
Publication
Application
Priority
- JP 2004002930 W 20040305
- US 45272003 P 20030307
Abstract (en)
[origin: WO2004078786A1] Compositions and methods for inhibiting inflammation of vessel wall and/or formation of neointimal hyperplasia by gene therapy using a soluble Flt-1 (sFlt-1) gene, are provided. VEGF has an essential role in the development of neointimal hyperplasia by causing inflammation. sFlt-1 gene transfer to the site of vascular injury blocks Flt-1-mediated VEGF signal transduction, thereby inhibiting early inflammation as well as late neointimal hyperplasia. The present invention is useful for inhibiting or treating inflammation of vessel wall and/or formation of neointimal hyperplasia in a patient with risk of post coronary intervention restenosis, atherosclerosis, arteriosclerosis, or edema.
IPC 1-7
IPC 8 full level
A61K 38/18 (2006.01); A61K 48/00 (2006.01); C07K 14/71 (2006.01)
CPC (source: EP)
A61K 48/005 (2013.01); A61P 3/06 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 29/00 (2017.12); C07K 14/71 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 2004078786A1
Citation (examination)
SHIBATA M. ET AL., HISTOCHEM CELL BIOL., vol. 116, 2001, pages 471 - 481
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004078786 A1 20040916; EP 1601696 A1 20051207; JP 2007528355 A 20071011
DOCDB simple family (application)
JP 2004002930 W 20040305; EP 04717875 A 20040305; JP 2006507662 A 20040305