EP 1601785 A4 20070207 - METHODS FOR DETECTION OF GENETIC DISORDERS
Title (en)
METHODS FOR DETECTION OF GENETIC DISORDERS
Title (de)
VERFAHREN ZUR ERKENNUNG GENETISCHER ERKRANKUNGEN
Title (fr)
METHODES POUR LA DETECTION DE TROUBLES GENETIQUES
Publication
Application
Priority
- US 0327308 W 20030829
- US 0306198 W 20030228
Abstract (en)
[origin: WO2004079011A1] The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.
IPC 1-7
IPC 8 full level
C07H 19/00 (2006.01); C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12Q 1/68 (2006.01)
IPC 8 main group level
C12Q (2006.01)
CPC (source: EP)
C07H 21/02 (2013.01); C07H 21/04 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6869 (2013.01)
Citation (search report)
- [XY] US 5618664 A 19970408 - KIESSLING ANN A [US]
- [Y] WO 03001181 A2 20030103 - QUEST DIAGNOSTICS INC [US], et al
- [A] WO 02055985 A2 20020718 - ROCHE DIAGNOSTICS CORP [US]
- [X] MAIWALD M ET AL: "Evaluation of the detection of Borrelia burgdorferi DNA in urine samples by polymerase chain reaction", INFECTION, MMV MEDIZIN VERLAG, MUENCHEN, DE, vol. 23, no. 3, May 1995 (1995-05-01), pages 173 - 179, XP008029303, ISSN: 0300-8126
- [Y] KÖSEL S ET AL: "Inter-laboratory comparison of DNA preservation in archival paraffin-embedded human brain tissue from participating centres on four continents.", NEUROGENETICS. JUL 2001, vol. 3, no. 3, July 2001 (2001-07-01), pages 163 - 170, XP002412462, ISSN: 1364-6745
- [Y] HIELM SEBASTIAN ET AL: "Genomic analysis of Clostridium botulinum group II by pulsed-field gel electrophoresis", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 64, no. 2, February 1998 (1998-02-01), pages 703 - 708, XP002412463, ISSN: 0099-2240
- [XY] LO Y M D ET AL: "QUANTITATIVE ANALYSIS OF FETAL DNA IN MATERNAL PLASMA AND SERUM: IMPLICATIONS FOR NONINVASIVE PRENATAL DIAGNOSIS", AMERICAN JOURNAL OF HUMAN GENETICS, UNIVERSITY OF CHICAGO PRESS, CHICAGO,, US, vol. 62, no. 4, April 1998 (1998-04-01), pages 768 - 775, XP009002852, ISSN: 0002-9297
- [XY] SIVA S C ET AL: "Evaluation of the clinical usefulness of isolation of fetal DNA from the maternal circulation", AUSTRALIAN AND NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, vol. 43, no. 1, 3 February 2003 (2003-02-03), pages 10 - 15, XP009024979, ISSN: 0004-8666
- [A] PERTL B ET AL: "FETAL DNA IN MATERNAL PLASMA: EMERGING CLINICAL APPLICATIONS", OBSTETRICS AND GYNECOLOGY, NEW YORK, NY, US, vol. 98, no. 3, September 2001 (2001-09-01), pages 483 - 490, XP001179125, ISSN: 0029-7844
- [T] DHALLAN RAVINDER ET AL: "Methods to increase the percentage of free fetal DNA recovered from the maternal circulation.", JAMA : THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 3 MAR 2004, vol. 291, no. 9, 3 March 2004 (2004-03-03), pages 1114 - 1119, XP009076430, ISSN: 1538-3598
- See references of WO 2004079011A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004079011 A1 20040916; AU 2003268333 A1 20040928; CA 2517017 A1 20040916; EP 1601785 A1 20051207; EP 1601785 A4 20070207; EP 1601793 A2 20051207; EP 1601793 A4 20070221; JP 2006521086 A 20060921; MX PA05009140 A 20060428; SG 173221 A1 20110829; WO 2004078994 A2 20040916; WO 2004078994 A3 20051013
DOCDB simple family (application)
US 0327308 W 20030829; AU 2003268333 A 20030829; CA 2517017 A 20030829; EP 03749291 A 20030829; EP 04716171 A 20040301; JP 2004569189 A 20030829; MX PA05009140 A 20030829; SG 2007063639 A 20030829; US 2004006337 W 20040301