EP 1605923 A2 20051221 - MSSN DISPERSION AND METHOD FOR PRODUCING THE SAME
Title (en)
MSSN DISPERSION AND METHOD FOR PRODUCING THE SAME
Title (de)
MSSN-DISPERSION UND VERFAHREN ZU IHRER HERSTELLUNG
Title (fr)
DISPERSION MSSN ET PROCEDE DE PRODUCTION DE LADITE DISPERSION
Publication
Application
Priority
- EP 2004001589 W 20040219
- DE 10312763 A 20030321
Abstract (en)
[origin: CA2519697A1] The invention relates to membrane-structured solid nanoparticles that have a n average particle diameter ranging from 10 to 10000 nm, that are solid at 25 ~C and that comprise a combination of active substance carrier particles and emulsifiers in such a manner that membranes penetrating the entire nanoparticles are formed so that emulsifiers are present in the interior and on the surface of the nanoparticles. The invention also relates to a method for producing an aqueous substance carrying dispersion in which solid active substance carrier particles on a wax, polymer or lipid basis having an avera ge diameter ranging from 10 to 10000 nm are present. Said particles contain at least one pharmaceutical, cosmetic and/or food technological active substanc e. The dispersion is produced by a) mixing, at a temperature above the melting or softening point of the active substance carrier, the active substance comprising the active substance carrier on a wax, polymer or lipid basis wit h at least one emulsifier that leads in step b) to the formation of a lyotropi c liquid-crystalline mixed phase and forming a phase B, b) mechanically mixing , at a temperature above the melting or softening point of the active substanc e carrier, phase B with an aqueous phase A that may contain an emulsifier, the weight ratio of phase B to phase A being 1:5 to 5:1, without using high- pressure homogenization, and forming a lyotropic liquid-crystalline mixed phase, c) diluting, to a desired final concentration of the dispersion, the mixed phase with an aqueous phase that may contain an emulsifier, at a temperature of the aqueous phase that is below the melting or softening poin t of the active substance carrier while stirring and without using high-pressu re homogenization.
IPC 1-7
IPC 8 full level
A61K 9/51 (2006.01)
CPC (source: EP KR US)
A61K 9/10 (2013.01 - KR); A61K 9/51 (2013.01 - KR); A61K 9/5123 (2013.01 - EP US); A61K 9/5146 (2013.01 - EP US); B82Y 5/00 (2013.01 - KR)
Citation (search report)
See references of WO 2004082666A2
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
DE 10312763 A1 20040930; AU 2004222631 A1 20040930; AU 2004222631 B2 20090226; CA 2519697 A1 20040930; CA 2519697 C 20110118; EP 1605923 A2 20051221; JP 2006520750 A 20060914; KR 20050114255 A 20051205; US 2006257334 A1 20061116; WO 2004082666 A2 20040930; WO 2004082666 A3 20050512
DOCDB simple family (application)
DE 10312763 A 20030321; AU 2004222631 A 20040219; CA 2519697 A 20040219; EP 04712492 A 20040219; EP 2004001589 W 20040219; JP 2006500036 A 20040219; KR 20057017689 A 20050921; US 55019304 A 20040219