EP 1608649 A2 20051228 - METHOD FOR THE ENANTIOSELECTIVE PREPARATION OF SULPHOXIDE DERIVATIVES
Title (en)
METHOD FOR THE ENANTIOSELECTIVE PREPARATION OF SULPHOXIDE DERIVATIVES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON ENANTIOSELEKTIVEN SULFOXID-DERIVATEN
Title (fr)
PROCEDE DE PREPARATION ENANTIOSELECTIVE DE DERIVES DE SULFOXYDES.
Publication
Application
Priority
- FR 2004000778 W 20040326
- FR 0303914 A 20030328
- FR 0314679 A 20031215
Abstract (en)
[origin: WO2004087702A2] The invention relates to a method for the enantioselective preparation of substituted sulphoxide derivatives. The method comprises carrying out an enantioselective oxidation of a sulphide of general formula (I): A - CH2 - S - B (I), where A = a variously-substituted pyridyl nucleus and B = a heterocyclic group with a benzimidazole or imidazopyridyl nucleus, by means of an oxidising agent in the presence of a catalyst based on tungsten or vanadium and a chiral ligand, followed, where necessary, by salt formation with a base to give the sulphoxide: A - CH2 - SO - B (Ia). The above is of application to the enantioselective preparation of compounds such as the enantiomers of tenatoprazole and other comparable sulphoxides.
IPC 1-7
IPC 8 full level
C07D 471/04 (2006.01)
CPC (source: EP KR US)
A61P 1/04 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/12 (2013.01 - KR); C07D 471/04 (2013.01 - EP KR US)
Citation (search report)
See references of WO 2004087702A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004087702 A2 20041014; WO 2004087702 A3 20041111; CA 2520157 A1 20041014; EP 1608649 A2 20051228; JP 2006523201 A 20061012; KR 20060002878 A 20060109; US 2006281782 A1 20061214
DOCDB simple family (application)
FR 2004000778 W 20040326; CA 2520157 A 20040326; EP 04742382 A 20040326; JP 2006505762 A 20040326; KR 20057018234 A 20050927; US 55103704 A 20040326