EP 1613732 A4 20120314 - INTRACELLULAR COMPLEXES AS BIOMARKERS
Title (en)
INTRACELLULAR COMPLEXES AS BIOMARKERS
Title (de)
INTRAZELLULÄRE KOMPLEXE ALS BIOMARKER
Title (fr)
COMPLEXES INTRACELLULAIRES UTILISES COMME BIOMARQUEURS
Publication
Application
Priority
- US 2004009805 W 20040330
- US 45988803 P 20030401
- US 62305703 A 20030717
- US 49448203 P 20030811
- US 50803403 P 20031001
- US 51294103 P 20031020
- US 52325803 P 20031118
Abstract (en)
[origin: WO2004091384A2] The invention is directed to a new class of biomarker in patient samples comprising dimers of ErbB cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of ErbB cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of ErbB cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more types of receptor dimers. After binding, molecular tags are released and separated from the assay mixture for analysis.
IPC 8 full level
G01N 33/53 (2006.01); C07K 16/28 (2006.01); C12Q 3/00 (2006.01); G01N 33/542 (2006.01); G01N 33/543 (2006.01); G01N 33/574 (2006.01)
IPC 8 main group level
CPC (source: EP)
C07K 16/2863 (2013.01); G01N 33/542 (2013.01); G01N 33/57492 (2013.01); G01N 2333/485 (2013.01); G01N 2800/52 (2013.01)
Citation (search report)
- [XY] WO 9524205 A1 19950914 - UNIV NEW YORK MED CT [US]
- [XPI] WO 03068808 A1 20030821 - GARVAN INST MED RES [AU], et al
- [E] WO 2005037071 A2 20050428 - ACLARA BIOSCIENCES INC [US], et al
- [YP] WO 03076649 A1 20030918 - ACLARA BIOSCIENCES INC [US], et al
- [XY] ZHA J ET AL: "Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL", CELL, CELL PRESS, US, vol. 87, 15 November 1996 (1996-11-15), pages 619 - 628, XP002110634, ISSN: 0092-8674, DOI: 10.1016/S0092-8674(00)81382-3
- [XPY] SHINODA SACHIKO ET AL: "Interaction of 14-3-3 with Bid during seizure-induced neuronal death.", JOURNAL OF NEUROCHEMISTRY, vol. 86, no. 2, July 2003 (2003-07-01), pages 460 - 469, XP002667074, ISSN: 0022-3042
- See references of WO 2004087887A2
Citation (examination)
WO 2004091384 A2 20041028 - ACLARA BIOSCIENCES INC [US], et al
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004091384 A2 20041028; WO 2004091384 A3 20051229; AU 2004225439 A1 20041014; AU 2004229348 A1 20041028; AU 2004230700 A1 20041028; BR PI0408928 A 20060912; BR PI0408950 A 20060328; BR PI0408961 A 20061031; CA 2521077 A1 20041028; CA 2521082 A1 20041028; CA 2521106 A1 20041014; EP 1613205 A2 20060111; EP 1613205 A4 20061129; EP 1613205 B1 20130424; EP 1613732 A2 20060111; EP 1613732 A4 20120314; EP 1613961 A2 20060111; EP 1613961 A4 20070307; JP 2006521821 A 20060928; JP 2006523314 A 20061012; WO 2004087887 A2 20041014; WO 2004087887 A3 20060615; WO 2004092353 A2 20041028; WO 2004092353 A3 20050303
DOCDB simple family (application)
US 2004009715 W 20040330; AU 2004225439 A 20040330; AU 2004229348 A 20040330; AU 2004230700 A 20040330; BR PI0408928 A 20040330; BR PI0408950 A 20040330; BR PI0408961 A 20040330; CA 2521077 A 20040330; CA 2521082 A 20040330; CA 2521106 A 20040330; EP 04758577 A 20040330; EP 04759064 A 20040330; EP 04759065 A 20040330; JP 2006509479 A 20040330; JP 2006509481 A 20040330; US 2004009717 W 20040330; US 2004009805 W 20040330