EP 1613760 A2 20060111 - FERMENTATION PROCESS FOR THE PREPARATION OF PRAVASTATIN
Title (en)
FERMENTATION PROCESS FOR THE PREPARATION OF PRAVASTATIN
Title (de)
FERMENTATIONSVERFAHREN ZUR HERSTELLUNG VON PRAVASTATIN
Title (fr)
PROCESSUS DE FERMENTATION POUR LA PREPARATION DE PRAVASTATINE
Publication
Application
Priority
- IB 2004001003 W 20040401
- IN 559DE2003 A 20030401
Abstract (en)
[origin: WO2004087935A2] The invention relates to a fermentation process for the preparation of substantially pure pravastatin. The process provides a method of producing pravastatin by microbial hydroxylation of compactin (ML-236B) by maintaining a concentration of compactin at not less than 300 µg /ml during the process. The process produces substantially pure pravastatin with reduced related impurities. The invention also relates to pharmaceutical compositions that include the substantially pure pravastatin.
IPC 1-7
C12P 7/62; C12P 17/06; C07C 67/00; A61K 31/215; C12P 7/62; C12R 1/465
IPC 8 full level
C07C 69/33 (2006.01); C12P 7/62 (2006.01); C12P 17/06 (2006.01)
CPC (source: EP)
C07C 69/33 (2013.01); C12P 7/62 (2013.01); C12P 17/06 (2013.01); C07C 2602/28 (2017.04)
Citation (search report)
See references of WO 2004087935A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004087935 A2 20041014; WO 2004087935 A3 20050113; CA 2521276 A1 20041014; EP 1613760 A2 20060111
DOCDB simple family (application)
IB 2004001003 W 20040401; CA 2521276 A 20040401; EP 04725114 A 20040401