EP 1616185 A2 20060118 - METHOD FOR SCREENING PROCESS CONDITIONS OF A CHEMICAL COUPLING REACTION AND KITS THEREFOR
Title (en)
METHOD FOR SCREENING PROCESS CONDITIONS OF A CHEMICAL COUPLING REACTION AND KITS THEREFOR
Title (de)
VERFAHREN UND KIT FÜR DAS SCREENING VON REAKTIONSBEDINGUNGEN VON CHEMISCHEN KUPPLUNGSREAKTIONEN
Title (fr)
PROCEDE DE CRIBLAGE DE CONDITIONS OPERATOIRES D UNE REACTION CHIMIQUE DE COUPLAGE ET TROUSSES POUR LA MISE EN OEUVRE DE CE PROCEDE
Publication
Application
Priority
- FR 2004050158 W 20040413
- FR 0350106 A 20030415
Abstract (en)
[origin: FR2853965A1] Method for screening the operating conditions for a coupling reaction between at least two functional groups. Method for screening the operating conditions for a coupling reaction between at least two functional groups comprises: (1) reacting at least two compounds, E1-X1-G1 and E2-X2-G2, in solution and under predetermined operating conditions, with at least one being a candidate operating condition (COC), to produce a compound (Z) of formula E1-X1-G1-G2-X2-E2; (2) determining the concentration of (Z) at a predetermined time (t), by at least one immunological assay, using at least one antibody (AC1) specific for the molecule (M1) of which E1 is the residue; and (3) evaluating the effect of one or more COC on the reaction, from the measured concentration of (Z). G1, G2 : first and second functional groups; X1 and X2 : covalent bonds or linkers; E1 : residue of molecule M1 for which a specific antibody (AC1) is available; E2 : residue of second molecule M2 for which a second antibody (AC2) is available, or a group able to form at least one covalent bond with AC1 in presence of a coupling agent An independent claim is also included for a kit for the new process.
IPC 1-7
IPC 8 full level
G01N 33/543 (2006.01)
CPC (source: EP US)
G01N 33/54306 (2013.01 - EP US)
Citation (search report)
See references of WO 2004092729A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
FR 2853965 A1 20041022; FR 2853965 B1 20060915; CA 2522432 A1 20041028; EP 1616185 A2 20060118; JP 2007527367 A 20070927; US 2007172905 A1 20070726; WO 2004092729 A2 20041028; WO 2004092729 A3 20050224
DOCDB simple family (application)
FR 0350106 A 20030415; CA 2522432 A 20040413; EP 04758930 A 20040413; FR 2004050158 W 20040413; JP 2006505875 A 20040413; US 55192904 A 20040413