EP 1622890 A2 20060208 - BLOCKERS OF THE QUORUM SENSING SYSTEM OF GRAM-NEGATIVE BACTERIA
Title (en)
BLOCKERS OF THE QUORUM SENSING SYSTEM OF GRAM-NEGATIVE BACTERIA
Title (de)
BLOCKER DES QUORUM-SENSING-SYSTEMS VON GRAMNEGATIVEN BAKTERIEN
Title (fr)
AGENTS BLOQUANTS DU SYSTÈME QUORUM SENSING DES BACTÉRIES GRAM-NÉGATIVES
Publication
Application
Priority
- EP 2004004850 W 20040506
- EP 03010185 A 20030506
- EP 04731333 A 20040506
Abstract (en)
[origin: EP1475092A1] The present invention relates to the use of compounds of the general Formula (XIII): <CHEM> wherein A<7> is C=O, C=S, SO2, CH-OR<13>, C=NR<12>, or CH2-CHOR<13>; A<8> is C(R<14>)2, O, S, or NR<12>; A<9> is C=O, C=S, SO2, CH-OR<13>, C=NR<12>, or CH2-CHOR<13>; m is 0, or 1 q is 0, or 1 r is 0, or 1 R<12> is H, CH3, CH2-CH3, OCH3, OCH2-CH3, OH, or SH; R<13> is H, CH3, or CH2-CH3; R<14> is H, alkyl, alkoxy, OH, or SH; as selective inhibitors of bacterial pathogens. In particular the invention refers to a family of compounds that block the quorum sensing system of Gram-negative bacteria, a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of microbial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.
IPC 1-7
C07D 333/38; C07D 307/68; C07D 295/18; C07D 275/02; C07D 273/00; C07D 231/40; C07D 231/12; C07D 215/08; C07D 211/60; C07D 211/34; C07D 211/02; C07D 209/86; C07D 209/08; C07D 209/42; C07D 207/32
IPC 8 full level
A61P 31/04 (2006.01); C07D 231/12 (2006.01); C07D 231/40 (2006.01); C07D 261/14 (2006.01); C07D 263/48 (2006.01); C07D 275/03 (2006.01); C07D 277/46 (2006.01); C07D 277/54 (2006.01); C07D 307/68 (2006.01); C07D 333/38 (2006.01); C07D 275/02 (2006.01)
CPC (source: EP)
A61P 31/04 (2017.12); C07D 231/40 (2013.01); C07D 261/14 (2013.01); C07D 263/48 (2013.01); C07D 275/03 (2013.01); C07D 277/46 (2013.01); C07D 277/54 (2013.01); C07D 307/68 (2013.01); C07D 333/38 (2013.01)
Citation (search report)
See references of WO 2004099175A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
EP 1475092 A1 20041110; CA 2526904 A1 20041118; EP 1622890 A2 20060208; WO 2004099175 A2 20041118; WO 2004099175 A3 20041229
DOCDB simple family (application)
EP 03010185 A 20030506; CA 2526904 A 20040506; EP 04731333 A 20040506; EP 2004004850 W 20040506