EP 1631311 A4 20070411 - HUMANIZED ANTI-CCR2 ANTIBODIES AND METHODS OF USE
Title (en)
HUMANIZED ANTI-CCR2 ANTIBODIES AND METHODS OF USE
Title (de)
HUMANISIERTE ANTI-CCR2-ANTIKÖRPER UND ANWENDUNGSVERFAHREN
Title (fr)
ANTICORPS HUMANISES ANTI-CCR2 ET LEURS PROCEDES D'UTILISATION
Publication
Application
Priority
US 0339599 W 20031210
Abstract (en)
[origin: WO2005060368A2] The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
IPC 8 full level
A61K 39/395 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP)
A61P 9/10 (2017.12); A61P 29/00 (2017.12); A61P 31/18 (2017.12); A61P 37/06 (2017.12); C07K 16/2866 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/71 (2013.01); C07K 2317/76 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
- [X] WO 0157226 A1 20010809 - MILLENNIUM PHARM INC [US], et al
- [X] US 2002150576 A1 20021017 - LAROSA GREGORY J [US], et al
- [X] WO 0170266 A2 20010927 - MILLENNIUM PHARM INC [US]
- See references of WO 2005060368A2
Citation (examination)
- WO 9958679 A1 19991118 - GLAXO GROUP LTD [GB], et al
- WO 02102853 A2 20021227 - ISIS INNOVATION [GB], et al
- WO 02062383 A2 20020815 - SMITHKLINE BEECHAM PLC [GB], et al
- WO 9958679 A1 19991118 - GLAXO GROUP LTD [GB], et al
- COMBADIERE: "Monocyte Chemoattractant Protein-3 is a functional ligand for CC Chemokine Receptors 1 and 2B", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 50, 1998, USA, pages 29671 - 29675
- ALBINI ADRIANA: "HIV-1 Tat protein mimicry of chemokines", PROC. NATL. ACAD. SCI., vol. 95, October 1998 (1998-10-01), USA, pages 13153 - 13158, XP002146039, DOI: 10.1073/pnas.95.22.13153
- GODISKA: "Monocte chemotactic protein-4: tissue-specific expression and signaling trhough CC chemokine receptor-2", J. LEUKOC. BIOL., vol. 61, March 1997 (1997-03-01), pages 353 - 360
- GONG: "Monocyte chemotactic protein-2 (MCP-2) uses CCR+ and CCR2B as its functional receptors", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 18, 2 May 1997 (1997-05-02), usa, pages 11682 - 11695
- SARAFI M.: "Murine Monocyte chemoattractant proetein (MCP)-5 a novel CC chemokine that is a structural and functional homologue of human MCP-1", J. EXP. MED., vol. 185, no. 1, 6 January 1997 (1997-01-06), USA, pages 99 - 109, XP055035882, DOI: 10.1084/jem.185.1.99
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005060368 A2 20050707; WO 2005060368 A3 20051222; AU 2003300896 A1 20050714; CA 2529694 A1 20050707; EP 1631311 A2 20060308; EP 1631311 A4 20070411; EP 2135619 A1 20091223; IL 172533 A0 20060410; IL 172533 A 20120229; JP 2007521248 A 20070802; MX PA06000176 A 20060627
DOCDB simple family (application)
US 0339599 W 20031210; AU 2003300896 A 20031210; CA 2529694 A 20031210; EP 03819151 A 20031210; EP 09169287 A 20031210; IL 17253305 A 20051213; JP 2005512414 A 20031210; MX PA06000176 A 20031210