EP 1631687 A2 20060308 - METHODS AND PRODUCTS FOR IDENTIFICATION AND ASSESSMENT OF TLR LIGANDS
Title (en)
METHODS AND PRODUCTS FOR IDENTIFICATION AND ASSESSMENT OF TLR LIGANDS
Title (de)
VERFAHREN UND PRODUKTE ZUR IDENTIFIZIERUNG UND BEURTEILUNG VON TLR-LIGANDEN
Title (fr)
PROCEDES ET PRODUITS POUR IDENTIFIER ET EVALUER DES LIGANDS DES TLR
Publication
Application
Priority
- US 2004012788 W 20040422
- US 46458603 P 20030422
- US 46458803 P 20030422
Abstract (en)
[origin: WO2004094671A2] The invention provides in part novel screening methods and compositions for identifying and distinguishing between candidate immunomodulatory compounds. The invention further provides methods for assessing biological activity of composition containing a known TLR ligand. These latter methods can be used for quality assessment and selection of various lots of test compositions, including pharmaceutical products for clinical use.
IPC 1-7
IPC 8 full level
C07K 14/705 (2006.01)
CPC (source: EP)
C07K 14/705 (2013.01)
Citation (search report)
See references of WO 2004094671A2
Citation (examination)
- TAKESHITA FUMIHIKO ET AL: "CpG ODN-mediated regulation of IL-12 p40 transcription", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 30, no. 7, July 2000 (2000-07-01), pages 1967 - 1976, ISSN: 0014-2980
- BRITIGAN B E ET AL: "Lactoferrin binds CpG-containing oligonucleotides and inhibits their immunostimulatory effects on human B cells.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 SEP 2001 LNKD- PUBMED:11509640, vol. 167, no. 5, 1 September 2001 (2001-09-01), pages 2921 - 2928, ISSN: 0022-1767
- BAUER S ET AL: "Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD- DOI:10.1073/PNAS.161293498, vol. 98, no. 16, 31 July 2001 (2001-07-31), pages 9237 - 9242, XP002221247, ISSN: 0027-8424
- MOESBY L ET AL: "Endotoxin testing of proteins for parenteral administration using the Mono Mac 6 assay", JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, vol. 25, no. 4, August 2000 (2000-08-01), pages 283 - 289, XP009135148, ISSN: 0269-4727
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL HR LT LV MK
DOCDB simple family (publication)
WO 2004094671 A2 20041104; WO 2004094671 A3 20050922; WO 2004094671 A9 20050127; EP 1631687 A2 20060308
DOCDB simple family (application)
US 2004012788 W 20040422; EP 04760178 A 20040422