EP 1633861 B1 20091104 - CRYSTALLINE VAP-1 AND USES THEREOF
Title (en)
CRYSTALLINE VAP-1 AND USES THEREOF
Title (de)
KRISTALLINER VAP-1 UND VERWENDUNG
Title (fr)
VAP-1 CRISTALLINE ET SES UTILISATIONS
Publication
Application
Priority
- FI 2004000318 W 20040525
- FI 20030786 A 20030526
- FI 20040271 A 20040220
Abstract (en)
[origin: WO2004104191A1] The present invention relates to crystalline vascular adhesion protein-1 (VAP-1) and in particular to methods for the use of structural information of crystalline human VAP-1 for ligand and/or inhibitor identification, design and production, as well as screening assays for detection of same. The invention further relates to inhibitors identified by the assays according to the present invention.
IPC 8 full level
C12N 9/00 (2006.01); B01D 9/00 (2006.01); C07K 14/705 (2006.01)
CPC (source: EP US)
A61P 1/00 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/08 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/705 (2013.01 - EP US); C07K 2299/00 (2013.01 - EP US)
Citation (examination)
- WO 0202090 A2 20020110 - BIOTIE THERAPIES CORP [FI], et al
- WO 03006003 A1 20030123 - BIOTIE THERAPIES CORP [FI], et al
- WO 2005080319 A1 20050901 - BIOTIE THERAPIES CORP [FI], et al
- MC PHERSON: "Crystallization of biological macromolecules", 1999, COLS SPRING HARBOR LABORATORY PRESS, NEW YORK
- CUDNEY B. ET AL: "Screening and optimization strategies for macromolecular growth", ACTA CRYST., vol. D50, 1994, pages 414 - 423, XP001098656
- JANCARIK J.; KIM S.-H.: "Sparse matrix sampling: a screening method for crystallization of proteins", J.APPL.CRYST., vol. 24, 1991, pages 409 - 411, XP000865937
- SMITH D.J. ET AL.: "Cloning of VAP-1 rreveals a novel multifunctional adhesion molecule", J.EXP.MED., vol. 188, no. 1, 1998, pages 17 - 27
- MCPHERSON: "introduction to protein crystallization", METHODS, vol. 34, 2004, pages 254 - 265
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL LT LV MK
DOCDB simple family (publication)
WO 2004104191 A1 20041202; WO 2004104191 A8 20050707; WO 2004104191 A8 20060817; AT E447610 T1 20091115; AU 2004241060 A1 20041202; AU 2004241060 B2 20090723; CA 2526675 A1 20041202; DE 602004023939 D1 20091217; DK 1633861 T3 20100322; EP 1633861 A1 20060315; EP 1633861 B1 20091104; ES 2335769 T3 20100405; HK 1086591 A1 20060922; JP 2007509605 A 20070419; NZ 543430 A 20080630; US 2007093646 A1 20070426; US 2011021760 A1 20110127; US 7499847 B2 20090303
DOCDB simple family (application)
FI 2004000318 W 20040525; AT 04734701 T 20040525; AU 2004241060 A 20040525; CA 2526675 A 20040525; DE 602004023939 T 20040525; DK 04734701 T 20040525; EP 04734701 A 20040525; ES 04734701 T 20040525; HK 06106381 A 20060602; JP 2006530308 A 20040525; NZ 54343004 A 20040525; US 35084409 A 20090108; US 55718804 A 20040525