EP 1638677 A4 20071010 - CATALYTIC ASYMMETRIC DESYMMETRIZATION OF PROCHIRAL AND MESO CYCLIC ANHYDRIDES
Title (en)
CATALYTIC ASYMMETRIC DESYMMETRIZATION OF PROCHIRAL AND MESO CYCLIC ANHYDRIDES
Title (de)
KATALYTISCHE ASYMMETRISCHE DESYMMETRISIERUNG VON PROCHIRALEN UND MESO-FORM AUFWEISENDEN CYCLISCHEN ANHYDRIDEN
Title (fr)
DESYMMETRISATION ASYMETRIQUE CATALYTIQUE D'ANHYDRIDES PROCHIRAUX ET MESOCYCLIQUES
Publication
Application
Priority
- US 2004018690 W 20040611
- US 47753103 P 20030611
- US 46005103 A 20030612
- US 48421803 P 20030701
Abstract (en)
[origin: WO2004110609A2] One aspect of the present invention relates to cinchona-alkaloid-based catalysts. A second aspect of the invention relates to a method of preparing a derivatized cinchona-alkaloid catalyst. Another aspect of the present invention relates to a method of preparing a chiral, nonracemic compound from a prochiral cyclic anhydride or a meso cyclic anhydride, comprising the step of: reacting a prochiral cyclic anhydride or a meso cyclic anhydride with a nucleophile in the presence of a derivatized cinchona-alkaloid catalyst. Yet another aspect of the present invention relates to a method of kinetic resolution, comprising the step of: reacting a racemic cyclic anhydride with an alcohol in the presence of a derivatized cinchona-alkaloid catalyst.
IPC 8 full level
C07D 453/04 (2006.01); C07C 69/34 (2006.01); C07D 453/02 (2006.01); C07D 487/00 (2006.01)
IPC 8 main group level
B01J (2006.01)
CPC (source: EP KR)
C07D 401/06 (2013.01 - KR); C07D 453/02 (2013.01 - KR); C07D 453/04 (2013.01 - EP)
Citation (search report)
- [X] WO 0174741 A2 20011011 - UNIV BRANDEIS [US]
- [PX] WO 03064420 A1 20030807 - DAISO CO LTD [JP], et al & EP 1477488 A1 20041117 - DAISO CO LTD [JP]
- [X] J. M. HUTZLER ET AL.: "inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues.", CHEM. RES. TOXICOL., vol. 16, no. 4, June 2003 (2003-06-01), us, pages 450 - 459, XP002437223
- See references of WO 2004110609A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004110609 A2 20041223; WO 2004110609 A3 20070104; CA 2529071 A1 20041223; CN 1956943 A 20070502; EP 1638677 A2 20060329; EP 1638677 A4 20071010; HR P20060010 A2 20060630; JP 2007531704 A 20071108; JP 4948172 B2 20120606; KR 20060070485 A 20060623
DOCDB simple family (application)
US 2004018690 W 20040611; CA 2529071 A 20040611; CN 200480022887 A 20040611; EP 04755066 A 20040611; HR P20060010 A 20060110; JP 2006529361 A 20040611; KR 20057023832 A 20051212