Global Patent Index - EP 1638677 A4

EP 1638677 A4 2007-10-10 - CATALYTIC ASYMMETRIC DESYMMETRIZATION OF PROCHIRAL AND MESO CYCLIC ANHYDRIDES

Title (en)

CATALYTIC ASYMMETRIC DESYMMETRIZATION OF PROCHIRAL AND MESO CYCLIC ANHYDRIDES

Title (de)

KATALYTISCHE ASYMMETRISCHE DESYMMETRISIERUNG VON PROCHIRALEN UND MESO-FORM AUFWEISENDEN CYCLISCHEN ANHYDRIDEN

Title (fr)

DESYMMETRISATION ASYMETRIQUE CATALYTIQUE D'ANHYDRIDES PROCHIRAUX ET MESOCYCLIQUES

Publication

EP 1638677 A4 (EN)

Application

EP 04755066 A

Priority

  • US 2004018690 W
  • US 47753103 P
  • US 46005103 A
  • US 48421803 P

Abstract (en)

[origin: WO2004110609A2] One aspect of the present invention relates to cinchona-alkaloid-based catalysts. A second aspect of the invention relates to a method of preparing a derivatized cinchona-alkaloid catalyst. Another aspect of the present invention relates to a method of preparing a chiral, non­racemic compound from a prochiral cyclic anhydride or a meso cyclic anhydride, comprising the step of: reacting a prochiral cyclic anhydride or a meso cyclic anhydride with a nucleophile in the presence of a derivatized cinchona-alkaloid catalyst. Yet another aspect of the present invention relates to a method of kinetic resolution, comprising the step of: reacting a racemic cyclic anhydride with an alcohol in the presence of a derivatized cinchona-alkaloid catalyst.

IPC 8 full level (invention and additional information)

C07D 453/04 (2006.01); C07C 69/34 (2006.01); C07D 453/02 (2006.01); C07D 487/00 (2006.01)

IPC 8 main group level (invention and additional information)

B01J (2006.01)

CPC (invention and additional information)

C07D 453/04 (2013.01)

Citation (search report)

  • [X] WO 0174741 A2 20011011 - UNIV BRANDEIS [US]
  • [PX] WO 03064420 A1 20030807 - DAISO CO LTD [JP], et al & EP 1477488 A1 20041117 - DAISO CO LTD [JP]
  • [X] J. M. HUTZLER ET AL.: "inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues.", CHEM. RES. TOXICOL., vol. 16, no. 4, June 2003 (2003-06-01), us, pages 450 - 459, XP002437223

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

EPO simple patent family

WO 2004110609 A2 20041223; WO 2004110609 A3 20070104; CA 2529071 A1 20041223; CN 1956943 A 20070502; EP 1638677 A2 20060329; EP 1638677 A4 20071010; HR P20060010 A2 20060630; JP 2007531704 A 20071108; JP 4948172 B2 20120606; KR 20060070485 A 20060623

INPADOC legal status


2010-07-21 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20100105

2007-10-31 [RIN1] INVENTOR (CORRECTION)

- Inventor name: DENG, LI

2007-10-31 [RIN1] INVENTOR (CORRECTION)

- Inventor name: LIU, XIAOFENG

2007-10-31 [RIN1] INVENTOR (CORRECTION)

- Inventor name: CHEN, YONGGANG

2007-10-31 [RIN1] INVENTOR (CORRECTION)

- Inventor name: TIAN, SHIKAIC/O DEPARTMENT OF CHEMISTRY

2007-10-10 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20070911

2007-07-18 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: C07D 453/04 20060101AFI20070614BHEP

2007-07-18 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: C07D 453/02 20060101ALI20070201BHEP

2007-07-18 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: C07C 69/34 20060101ALI20070201BHEP

2007-07-18 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: C07D 487/00 20060101ALI20070201BHEP

2007-03-07 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: C07C 55/00 20060101AFI20070201BHEP

2007-03-07 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: C07D 453/02 20060101ALI20070201BHEP

2007-03-07 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: C07C 69/34 20060101ALI20070201BHEP

2007-03-07 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: C07D 487/00 20060101ALI20070201BHEP

2006-09-20 [DAX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT (TO ANY COUNTRY) DELETED

2006-03-29 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20051230

2006-03-29 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

2006-03-29 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Countries: AL HR LT LV MK