EP 1644322 A1 20060412 - ASPARTYL PROTEASE INHIBITORS
Title (en)
ASPARTYL PROTEASE INHIBITORS
Title (de)
ASPARTYL PROTEASE INHIBITOREN
Title (fr)
INHIBITEURS D'ASPARTYL-PROTEASE
Publication
Application
Priority
- US 0339276 W 20031210
- US 46212703 A 20030616
- US 0318858 W 20030616
Abstract (en)
[origin: WO2005005374A1] The present invention provides compounds having the formula: (I) wherein R<1>, R', R<2>, R<3>, R<3'>, R<4>, X<1>, X<2> and X<3> are as defined herein, and pharmaceutical compositions thereof. The present invention also provides methods of inhibiting proteases, more specifically aspartyl proteases. In certain embodiments, compounds inhibit BACE (beta-site APP-cleaving enzyme), and thus are useful in the treatment or prevention of a disease characterized by beta-amyloid deposits in the brain (including, but not limited to, Alzheimer's Disease). The present invention also provides methods for preparing compounds of the invention.
IPC 1-7
C07C 237/22; C07C 237/12; C07C 237/14; C07D 333/02; C07D 307/02; C07D 211/04; C07D 249/08; C07C 311/16; C07C 311/08; C07D 275/02; C07D 285/06; C07D 213/04; A61K 31/166; A61P 25/28; C07K 5/02; C07D 241/08
IPC 8 full level
A61P 25/28 (2006.01); C07D 207/08 (2006.01); C07D 213/81 (2006.01); C07D 213/82 (2006.01); C07D 241/08 (2006.01); C07D 249/08 (2006.01); C07D 275/02 (2006.01); C07D 285/10 (2006.01); C07D 295/192 (2006.01); C07D 333/38 (2006.01); C07D 401/06 (2006.01); C07D 409/06 (2006.01); C07K 5/02 (2006.01)
CPC (source: EP)
A61P 25/28 (2017.12); C07C 237/12 (2013.01); C07C 237/14 (2013.01); C07C 237/22 (2013.01); C07D 207/08 (2013.01); C07D 213/81 (2013.01); C07D 213/82 (2013.01); C07D 241/08 (2013.01); C07D 275/02 (2013.01); C07D 285/10 (2013.01); C07D 295/192 (2013.01); C07D 333/38 (2013.01); C07D 401/06 (2013.01); C07D 409/06 (2013.01); C07K 5/0207 (2013.01)
Citation (search report)
See references of WO 2005005374A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005005374 A1 20050120; AU 2003297826 A1 20050128; CA 2529739 A1 20050120; EP 1644322 A1 20060412
DOCDB simple family (application)
US 0339276 W 20031210; AU 2003297826 A 20031210; CA 2529739 A 20031210; EP 03796897 A 20031210