EP 1651235 A2 20060503 - SIGMA-1 RECEPTOR LIGAND WITH ACETYLCHOLINESTERASE INHIBITION PROPERTIES
Title (en)
SIGMA-1 RECEPTOR LIGAND WITH ACETYLCHOLINESTERASE INHIBITION PROPERTIES
Title (de)
SIGMA-1 REZEPTOR-LIGAND MIT ACETYLCHOLINESTERASE-HEMMENDEN EIGENSCHAFTEN
Title (fr)
LIGAND DU RECEPTEUR SIGMA-1 PRESENTANT DES PROPRIETES D'INHIBITION DE L'ACETYLCHOLINESTERASE
Publication
Application
Priority
- US 2004025295 W 20040805
- US 49276903 P 20030805
Abstract (en)
[origin: WO2005016276A2] A novel compound and method for preventing or treating neurodegenerative diseases by inhibiting acetylcholinesterase and binding the sigma-1 receptor are disclosed. Dimethylcarbamic acid 2,3-bis-dimethylcarbamoyloxy-6-[4-(4-ethyl-piperazin-yl)-butyryl]-phenyl ester and its derivatives represent a novel therapeutic strategy against beta-amyloid peptide induced neurotoxicity, in inhibiting acetylcholinesterase, in improving cholinergic transmission, in binding the sigma-l receptor, and in releasing a metabolite that is active both as a sigma-1 receptor ligand and an antioxidant.
IPC 1-7
IPC 8 full level
A61K 31/495 (2006.01); A61K 31/56 (2006.01); A61P 25/28 (2006.01); C07D 241/04 (2006.01)
IPC 8 main group level
A61K (2006.01)
CPC (source: EP)
A61K 31/495 (2013.01); A61P 25/00 (2017.12); A61P 25/28 (2017.12); A61P 43/00 (2017.12)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL HR LT LV MK
DOCDB simple family (publication)
WO 2005016276 A2 20050224; WO 2005016276 A3 20050707; AU 2004264342 A1 20050224; CA 2534777 A1 20050224; CN 1863536 A 20061115; EP 1651235 A2 20060503; EP 1651235 A4 20081217; JP 2007501254 A 20070125
DOCDB simple family (application)
US 2004025295 W 20040805; AU 2004264342 A 20040805; CA 2534777 A 20040805; CN 200480028827 A 20040805; EP 04757425 A 20040805; JP 2006522719 A 20040805