EP 1656367 A1 20060517 - 4- (HETEROCYCLYL- FUSED PHENYL)- 3- (PHENYL OR PYRID -2- YL) PYRAZOLES AS INHIBITORS OF THE ALK-5- RECEPTOR
Title (en)
4- (HETEROCYCLYL- FUSED PHENYL)- 3- (PHENYL OR PYRID -2- YL) PYRAZOLES AS INHIBITORS OF THE ALK-5- RECEPTOR
Title (de)
4-(HETEROCYCLYLKONDENSIERTES PHENYL)-3-(PHENYL- ODER -PYRID-2-YL)PYRAZOLE ALS INHIBITOREN DES ALK-5-REZEPTORS
Title (fr)
4-(HETEROCYCLYLE-PHENYLE FUSIONNE)-3-PHENYLE OU PYRID-2-YLE)PYRAZOLES UTILISES COMME INHIBITEURS DU RECEPTEUR DE ALK-5
Publication
Application
Priority
- EP 2004006427 W 20040614
- GB 0313915 A 20030616
Abstract (en)
[origin: WO2004111036A1] The invention relates to novel pyrazole derivatives which are inhibitors of the transforming growth factor, ("TGF")-beta signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-beta type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.
IPC 1-7
IPC 8 full level
A61P 13/12 (2006.01); C07D 401/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01)
CPC (source: EP)
A61P 13/12 (2017.12); C07D 401/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01)
Citation (search report)
See references of WO 2004111036A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2004111036 A1 20041223; EP 1656367 A1 20060517; GB 0313915 D0 20030723; JP 2006527722 A 20061207
DOCDB simple family (application)
EP 2004006427 W 20040614; EP 04739898 A 20040614; GB 0313915 A 20030616; JP 2006515936 A 20040614