EP 1658312 A1 20060524 - MODULATORS OF THE POTASSIUM CHANNELS TWIK-1, TASK-1, GIRK1, SK2 OR PCN1, USED TO TREAT ARRHYTHMIA, CORONARY HEART DISEASE OR HYPERTENSION
Title (en)
MODULATORS OF THE POTASSIUM CHANNELS TWIK-1, TASK-1, GIRK1, SK2 OR PCN1, USED TO TREAT ARRHYTHMIA, CORONARY HEART DISEASE OR HYPERTENSION
Title (de)
MODULATOREN DER KALIUMKANÄLE TWIK-1, TASK-1, GIRK1, SK2 ODER PCN1 ZUR BEHANDLUNG VON ARRHYTHMIEN, KORONARER HERZKRANKHEITEN ODER BLUTHOCHDRUCK
Title (fr)
MODULATEURS DES CANAUX POTASSIUM TWIK-1, TASK-1, GIRK1, SK2 OU PCN1 POUR LE TRAITEMENT DES ARYTHMIES, DES CORONAROPATHIES OU DE L'HYPERTENSION
Publication
Application
Priority
- EP 2004007364 W 20040706
- DE 10332685 A 20030718
Abstract (en)
[origin: DE10332685A1] Use of at least one modulator (I) of the potassium channels TWIK-1, TASK-1, GIRK1, SK2 or PCN1 for preparing a composition for the treatment and/or prophylaxis of cardiac rhythm disorders, coronary heart disease and hypertension. Independent claims are also included for the following: (1) screening compounds to identify (I); (2) (I) as new compounds; and (3) use of modulators (Ia) of gene products that are differentially expressed in the heart between the left atrium and left ventricle, to prepare a composition for treatment of cardiac rhythm disorders, coronary heart disease and hypertension. ACTIVITY : Antiarrhythmic; Cardiant; Hypotensive. No details of tests for these activities are given. MECHANISM OF ACTION : Modulation of potassium channels preferentially expressed in the atrium.
IPC 1-7
IPC 8 full level
A61P 9/06 (2006.01); C07K 14/705 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP US)
A61P 9/00 (2017.12 - EP); A61P 9/06 (2017.12 - EP); C07K 14/705 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (search report)
See references of WO 2005016965A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
DE 10332685 A1 20050217; EP 1658312 A1 20060524; US 2006183665 A1 20060817; WO 2005016965 A1 20050224
DOCDB simple family (application)
DE 10332685 A 20030718; EP 04740690 A 20040706; EP 2004007364 W 20040706; US 56518504 A 20040706