EP 1660001 A4 20101215 - CROSSLINKING REAGENT FOR TREATING VERTEBRAL DISC DISORDERS
Title (en)
CROSSLINKING REAGENT FOR TREATING VERTEBRAL DISC DISORDERS
Title (de)
VERNETZUNGSMITTEL ZUR BEHANDLUNG VON BANDSCHEIBENSCHÄDEN
Title (fr)
REACTIFS DE RETICULATION DESTINES A TRAITER DES TROUBLES DES DISQUES INTERVERTEBRAUX
Publication
Application
Priority
- US 2004028039 W 20040827
- US 49879003 P 20030828
- US 78686104 A 20040224
- US 23067102 A 20020829
- US 31628701 P 20010831
Abstract (en)
[origin: WO2005020862A1] A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and devices for enhancing the body's own efforts to stabilize discs in scoliotic spines by increasing collagen crosslinks. This stability enhancement is caused by reducing the bending hysteresis and increasing the bending stiffness of scoliotic spines, by injecting non-toxic crosslinking reagents into the convex side of discs involved in the scoliotic curve. Alternatively, contact between the tissue and the crosslinking reagent is effected by placement of a time-release delivery system directly into or onto the target tissue. Methods and devices that use crosslinking agents for increasing the permeability of an intervertebral disc, improving fluid flux to the intervertebral disc, and increasing the biological viability of cells within the intervertebral disc are provided.
IPC 8 full level
A61F 2/00 (2006.01); A61F 13/00 (2006.01); A61K 9/00 (2006.01); A61K 31/353 (2006.01); A61K 31/70 (2006.01); A61K 31/7048 (2006.01)
CPC (source: EP US)
A61K 9/0019 (2013.01 - EP US); A61K 31/353 (2013.01 - EP US); A61K 31/70 (2013.01 - EP US); A61K 31/7048 (2013.01 - EP US); A61P 19/00 (2017.12 - EP); A61P 41/00 (2017.12 - EP)
Citation (search report)
- [X] US 2003049301 A1 20030313 - HEDMAN THOMAS P [US]
- [X] WO 03020031 A1 20030313 - UNIV SOUTHERN CALIFORNIA [US], et al
- [XPA] EP 1346736 A1 20030924 - DEPUY ACROMED INC [US]
- See references of WO 2005020862A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005020862 A1 20050310; WO 2005020862 A8 20050519; AU 2004268628 A1 20050310; AU 2004268628 B2 20091112; CA 2536415 A1 20050310; CA 2536415 C 20130723; EP 1660001 A1 20060531; EP 1660001 A4 20101215; EP 1660001 B1 20191009; JP 2007504162 A 20070301; JP 4955388 B2 20120620; TW 200526203 A 20050816; US 2010266544 A1 20101021; US 8450276 B2 20130528
DOCDB simple family (application)
US 2004028039 W 20040827; AU 2004268628 A 20040827; CA 2536415 A 20040827; EP 04782506 A 20040827; JP 2006524909 A 20040827; TW 93125979 A 20040827; US 81667410 A 20100616