Global Patent Index - EP 1666045 A1

EP 1666045 A1 20060607 - Sphingomyelin containing preparation for the treatment of rheumatoid arthritis

Title (en)

Sphingomyelin containing preparation for the treatment of rheumatoid arthritis

Title (de)

Sphingomyelin enthaltende Zusammensetzung zur Behandlung der rheumatoiden Arthritis

Title (fr)

Préparation contenant de la sphingomyéline pour le traitement de la polyarthrite rhumatoide

Publication

EP 1666045 A1 20060607 (EN)

Application

EP 06075201 A 20000324

Priority

  • EP 00916269 A 20000324
  • US 12618999 P 19990325

Abstract (en)

Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing the levels of sphingomyelin in all cellular compartments, thereby providing sufficient substrate for activated sphingomyelinase. A method of treating rheumatoid arthritis also is provided.

IPC 8 full level

A61K 31/688 (2006.01); A61K 47/42 (2006.01); A61K 31/513 (2006.01); A61K 31/704 (2006.01); A61K 45/06 (2006.01); A61K 51/00 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01)

CPC (source: EP US)

A61K 31/513 (2013.01 - EP US); A61K 31/688 (2013.01 - EP US); A61K 31/704 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 19/02 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP)

C-Set (source: EP US)

  1. A61K 31/513 + A61K 2300/00
  2. A61K 31/688 + A61K 2300/00
  3. A61K 31/704 + A61K 2300/00

Citation (applicant)

  • "Cancer imaging with radiolabeled antibodies", 1990, KLUWER ACADEMIC PUBLISHERS
  • "Cancer Therapy with Radiolabeled Antibodies", 1995, CRC PRESS
  • KRENNING ET AL., J. NUCL. MED., vol. 33, 1992, pages 652 - 658
  • KISHIDA ET AL., J. LIPID MEDIAT. CELL SIGNAL, vol. 16, 1997, pages 127 - 137
  • SAMBROOK ET AL.: "Molecular Cloning, A Laboratorv Manual", 1989, COLD SPRING HARBOR PRESS
  • ROSENBERG ET AL., SCIENCE, vol. 242, 1988, pages 1575 - 1578
  • WOLFF ET AL., PNAS, vol. 86, 1989, pages 9011 - 9014
  • CAPLEN ET AL., NATURE MED., vol. 1, 1995, pages 39 - 46
  • ZHU ET AL., SCIENCE, vol. 261, 1993, pages 209 - 211
  • BERKNER ET AL., BIOTECHNIQUES, vol. 6, 1988, pages 616 - 629
  • TRAPNELL ET AL., ADVANCED DRUG DELIVERY REV., vol. 12, 1993, pages 185 - 199
  • HODGSON ET AL., BIOTECHNOLOGY, vol. 13, 1995, pages 222

Citation (search report)

  • [X] MODRAK, D. E. ET AL: "Sphingomyelin potentiation of chemotherapy in HT-29 bearing nude mice.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, (MARCH, 1999) VOL. 40, PP. 483-484. MEETING INFO.: 90TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH PHILADELPHIA, PENNSYLVANIA, USA APRIL 10-14, 1999 AMERI, 15 March 1999 (1999-03-15), XP000925541
  • [A] ELORZA B ET AL: "Characterization of 5-fluorouracil loaded liposomes prepared by reverse-phase evaporation or freezing-thawing extrusion methods: study of drug release.", BIOCHIMICA ET BIOPHYSICA ACTA. 12 DEC 1993, vol. 1153, no. 2, 12 December 1993 (1993-12-12), pages 135 - 142, XP000925687, ISSN: 0006-3002
  • [A] ANGHILERI L J: "Ca2+-transport inhibition by the antitumor agents adriamycin and daunomycin.", ARZNEIMITTEL-FORSCHUNG. 1977, vol. 27, no. 6, 1977, pages 1177 - 1180, XP000929428, ISSN: 0004-4172
  • [A] CHEUNG B C ET AL: "Loading of doxorubicin into liposomes by forming Mn2+-drug complexes.", BIOCHIMICA ET BIOPHYSICA ACTA. 11 NOV 1998, vol. 1414, no. 1-2, 11 November 1998 (1998-11-11), pages 205 - 216, XP000933460, ISSN: 0006-3002
  • [AD] ICHINOSE Y ET AL: "ORIGINAL ARTICLES APOPTOSIS INDUCTION IN SYNOVIAL FIBROBLASTS BY CERAMIDE: IN VITRO AND IN VIVO EFFECTS", JOURNAL OF LABORATORY AND CLINICAL MEDICINE, ST. LOUIS, MO, US, vol. 131, May 1998 (1998-05-01), pages 410 - 416, XP000973390, ISSN: 0022-2143
  • [A] MIZUSHIMA NOBORU ET AL: "Ceramide induces apoptosis of synovial cells", ARTHRITIS AND RHEUMATISM, vol. 39, no. 9 SUPPL., 1996, & 60TH NATIONAL SCIENTIFIC MEETING OF THE AMERICAN COLLEGE OF RHEUMATOLOGY AND THE 31ST NATIONAL SCIEN; ORLANDO, FLORIDA, USA; OCTOBER 18-22, 1996, pages S80, XP009064949, ISSN: 0004-3591
  • [A] DATABASE WPI Section Ch Week 198320, Derwent World Patents Index; Class B05, AN 1983-47914K, XP002376061

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0057916 A1 20001005; AT E334686 T1 20060815; AT E512664 T1 20110715; AU 3740000 A 20001016; CA 2368676 A1 20001005; CA 2368676 C 20100907; CA 2707691 A1 20001005; CA 2707691 C 20130903; DE 60029762 D1 20060914; DE 60029762 T2 20071018; EP 1165137 A1 20020102; EP 1165137 B1 20060802; EP 1666045 A1 20060607; EP 1666045 B1 20110615; ES 2269121 T3 20070401; JP 2002540172 A 20021126; US 2003228257 A1 20031211; US 6541462 B1 20030401; US 7288534 B2 20071030

DOCDB simple family (application)

US 0006431 W 20000324; AT 00916269 T 20000324; AT 06075201 T 20000324; AU 3740000 A 20000324; CA 2368676 A 20000324; CA 2707691 A 20000324; DE 60029762 T 20000324; EP 00916269 A 20000324; EP 06075201 A 20000324; ES 00916269 T 20000324; JP 2000607665 A 20000324; US 36670403 A 20030214; US 53379900 A 20000324