Global Patent Index - EP 1667516 A4

EP 1667516 A4 20091111 - METHOD OF SELECTING ANIMAL MODELS FROM ANIMALS WHICH HAVE BEEN SUBJECT TO MUTAGENESIS, AND THE USE OF MYB TRANSCRIPTION FACTORS FOR SCREENING

Title (en)

METHOD OF SELECTING ANIMAL MODELS FROM ANIMALS WHICH HAVE BEEN SUBJECT TO MUTAGENESIS, AND THE USE OF MYB TRANSCRIPTION FACTORS FOR SCREENING

Title (de)

VERFAHREN ZUR AUSWAHL VON TIERMODELLEN VON TIEREN, DIE MUTAGENESE UNTERZOGEN WORDEN SIND, UND VERWENDUNG VON MYB-TRANSKRIPTIONSFAKTOREN ZUM SCREENING

Title (fr)

PROCEDE DE SELECTION DE MODELES D'ANIMAUX PARMI LES ANIMAUX AYANT ETE SOUMIS A LA MUTAGENESE, ET UTILISATION DE FACTEURS DE TRANSCRIPTION MYB POUR LE CRIBLAGE

Publication

EP 1667516 A4 20091111 (EN)

Application

EP 04761204 A 20040827

Priority

  • AU 2004001167 W 20040827
  • AU 2003904850 A 20030829
  • AU 2003904686 A 20030829
  • AU 2003904726 A 20030901
  • AU 2003905351 A 20030901
  • AU 2003907191 A 20031224

Abstract (en)

[origin: WO2005020677A1] The present invention relates generally to target molecules for potential therapeutic and/or prophylactic intervention. More particularly, the present invention provides a physiological assessment system in the form of vertebrate animal models to identify genetic or proteinaceous drug targets therein associated with a disease or a particular condition or phenotype. In an illustrative embodiment, target molecules associated with modulating platelet levels and ameliorating the symptoms of thrombocytopenia are described. The target molecules are useful as therapeutic and/or prophylactic agents such as in antisense or iRNA form. The present invention also relates to the application of these drug targets in the identification or development of therapeutic and/or prophylactic agents which modulate the functional activity of the drug target or its interacting network of molecules.

IPC 8 full level

A01K 67/00 (2006.01); A01K 67/027 (2006.01); C12N 15/85 (2006.01)

CPC (source: EP)

A01K 67/027 (2013.01); A01K 67/0275 (2013.01); C12N 15/8509 (2013.01); A01K 2217/03 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0306 (2013.01)

Citation (search report)

  • [XY] NOLAN PM, HUGILL A, COX RD.: "NU mutagenesis in the mouse: application to human genetic disease.", BRIEF FUNCT GENOMIC PROTEOMIC., vol. 1, no. 3, October 2002 (2002-10-01), pages 278 - 289, XP002542203
  • [XY] THAUNG C, WEST K, CLARK BJ, MCKIE L, MORGAN JE, ARNOLD K, NOLAN PM, PETERS J, HUNTER AJ, BROWN SD, JACKSON IJ, CROSS SH.: "Novel ENU-induced eye mutations in the mouse: models for human eye disease.", HUM MOL GENET., vol. 11, no. 7, April 2002 (2002-04-01), pages 755 - 767, XP002542204
  • [XY] RUSS A. ET AL.: "9: Chemical mutagenesis in the mouse : a powerful tool in drug target identification and validation", 1 January 2003, JOHM WILEY &SONS, XP002542208
  • [XY] CUMMINGS CJ, SUN Y, OPAL P, ANTALFFY B, MESTRIL R, ORR HT, DILLMANN WH, ZOGHBI HY.: "Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice.", HUM MOL GENET., vol. 10, no. 14, 1 July 2001 (2001-07-01), pages 1511 - 1518, XP002542205
  • [XY] J RULAND, C SIRARD, A E D MACPHERSON, A WAKEHAM, L LI, J L DE LA POMPA, S N. COHEN, T W. MAK: "p53 Accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101", PROC NATL ACAD SCI U S A., vol. 98, no. 4, 13 February 2001 (2001-02-13), pages 1859 - 1864, XP002542206
  • [A] JORGENSEN E M ET AL: "THE ART AND DESIGN OF GENETIC SCREENS: CAENORHABDITIS ELEGANS", NATURE REVIEWS GENETICS, MACMILLAN MAGAZINES, GB, vol. 3, no. 5, 1 May 2002 (2002-05-01), pages 356 - 359, XP008019110
  • [A] .PERCEC I, THORVALDSEN JL, PLENGE RM, KRAPP CJ, NADEAU JH, WILLARD HF, BARTOLOMEI MS.: "An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse", GENETICS., vol. 164, no. 4, 1 August 2003 (2003-08-01), pages 1481 - 1494, XP002542207
  • See references of WO 2005020677A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2005020677 A1 20050310; EP 1667516 A1 20060614; EP 1667516 A4 20091111

DOCDB simple family (application)

AU 2004001167 W 20040827; EP 04761204 A 20040827