Global Patent Index - EP 1667672 A4

EP 1667672 A4 2010-02-10 - METHOD FOR PREVENTING AND/OR TREATING NEURODEGENERATIVE DISEASES

Title (en)

METHOD FOR PREVENTING AND/OR TREATING NEURODEGENERATIVE DISEASES

Title (de)

VERFAHREN ZUR PRÄVENTION UND/ODER BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN

Title (fr)

PROCEDE DE PREVENTION ET/OU DE TRAITEMENT DE MALADIES NEURODEGENERATIVES

Publication

EP 1667672 A4 (EN)

Application

EP 04773691 A

Priority

  • JP 2004014893 W
  • US 50795203 P
  • JP 2004174577 A

Abstract (en)

[origin: WO2005032537A1] The invention relates to a neurodegenerative disease treating agent for parenteral use, which comprises (2R)-2-propyloctanoic acid or a salt thereof. Since the neurodegenerative disease treating agent of the present invention comprising (2R)-2-propyloctanoic acid or a salt thereof, characterized in that a dosage exceeding about 100 mg per dose is parenterally administered, shows neuropathy improving effect and S-100 beta increase inhibiting efffect in patients with cerebral infarction, it is useful for the treatment of neurodegenerative diseases including cerebral infarction. In addition, it is also useful as a neural regeneration agent after transplantation.

IPC 8 full level (invention and additional information)

A61K 31/20 (2006.01); A61K 9/70 (2006.01); A61K 47/02 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01)

CPC (invention and additional information)

A61K 47/02 (2013.01); A61K 9/0019 (2013.01); A61K 31/195 (2013.01); A61K 31/20 (2013.01)

Combination set (CPC)

A61K 31/20 + A61K 2300/00

Citation (search report)

  • [X] HONJO K ET AL: "Effects of ONO-2506 combined with thrombolytic therapy in a rat model of thrombotic focal cerebral ischemia", ABSTRACTS OF THE ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE, SOCIETY FOR NEUROSCIENCE, WASHINGTON, DC, US, vol. 27, no. 2, 10 November 2001 (2001-11-10), pages 2301, XP001539303, ISSN: 0190-5295
  • [X] TATEISHI NARITO ET AL: "Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurologic deficits", JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM : OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF CEREBRAL BLOOD FLOW AND METABOLISM JUN 2002,, vol. 22, no. 6, 1 June 2002 (2002-06-01), pages 723 - 734, XP002552189
  • [PX] ASANO T ET AL: "Arundic acid (ONO-2506) ameliorates delayed ischemic brain damage by preventing astrocytic overproduction of S100B", CURRENT DRUG TARGETS. CNS & NEUROLOGICAL DISORDERS, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, vol. 4, no. 2, 1 April 2005 (2005-04-01), pages 127 - 142, XP009124642, ISSN: 1568-007X
  • [PX] FOR THE ARUNDIC ACID (ONO-2506) STROKE STUDY GROUP ET AL: "Safety and tolerability of arundic acid in acute ischemic stroke", JOURNAL OF NEUROLOGICAL SCIENCES, ELSEVIER SCIENTIFIC PUBLISHING CO, AMSTERDAM, NL, vol. 251, no. 1-2, 21 December 2006 (2006-12-21), pages 50 - 56, XP025190710, ISSN: 0022-510X, [retrieved on 20061221]
  • See also references of WO 2005032537A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

EPO simple patent family

WO 2005032537 A1 20050414; EP 1667672 A1 20060614; EP 1667672 A4 20100210; JP 2007507490 A 20070329; JP 2012046543 A 20120308; JP 5485497 B2 20140507

INPADOC legal status


2014-08-20 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20140228

2013-11-13 [INTG] ANNOUNCEMENT OF INTENTION TO GRANT

- Effective date: 20131017

2011-09-28 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20110829

2010-02-10 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20100112

2007-01-10 [DAX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT (TO ANY COUNTRY) DELETED

2006-06-14 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20060331

2006-06-14 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR