EP 1667672 A4 20100210 - METHOD FOR PREVENTING AND/OR TREATING NEURODEGENERATIVE DISEASES
Title (en)
METHOD FOR PREVENTING AND/OR TREATING NEURODEGENERATIVE DISEASES
Title (de)
VERFAHREN ZUR PRÄVENTION UND/ODER BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN
Title (fr)
PROCEDE DE PREVENTION ET/OU DE TRAITEMENT DE MALADIES NEURODEGENERATIVES
Publication
Application
Priority
- JP 2004014893 W 20041001
- US 50795203 P 20031003
- JP 2004174577 A 20040611
Abstract (en)
[origin: WO2005032537A1] The invention relates to a neurodegenerative disease treating agent for parenteral use, which comprises (2R)-2-propyloctanoic acid or a salt thereof. Since the neurodegenerative disease treating agent of the present invention comprising (2R)-2-propyloctanoic acid or a salt thereof, characterized in that a dosage exceeding about 100 mg per dose is parenterally administered, shows neuropathy improving effect and S-100 beta increase inhibiting efffect in patients with cerebral infarction, it is useful for the treatment of neurodegenerative diseases including cerebral infarction. In addition, it is also useful as a neural regeneration agent after transplantation.
IPC 8 full level
A61K 9/70 (2006.01); A61K 31/20 (2006.01); A61K 47/02 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP)
A61K 9/0019 (2013.01); A61K 31/195 (2013.01); A61K 31/20 (2013.01); A61K 47/02 (2013.01); A61P 7/02 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 25/00 (2017.12); A61P 25/28 (2017.12); A61P 43/00 (2017.12)
Citation (search report)
- [X] HONJO K ET AL: "Effects of ONO-2506 combined with thrombolytic therapy in a rat model of thrombotic focal cerebral ischemia", ABSTRACTS OF THE ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE, SOCIETY FOR NEUROSCIENCE, WASHINGTON, DC, US, vol. 27, no. 2, 10 November 2001 (2001-11-10), pages 2301, XP001539303, ISSN: 0190-5295
- [X] TATEISHI NARITO ET AL: "Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurologic deficits", JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM : OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF CEREBRAL BLOOD FLOW AND METABOLISM JUN 2002,, vol. 22, no. 6, 1 June 2002 (2002-06-01), pages 723 - 734, XP002552189
- [PX] ASANO T ET AL: "Arundic acid (ONO-2506) ameliorates delayed ischemic brain damage by preventing astrocytic overproduction of S100B", CURRENT DRUG TARGETS. CNS & NEUROLOGICAL DISORDERS, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, vol. 4, no. 2, 1 April 2005 (2005-04-01), pages 127 - 142, XP009124642, ISSN: 1568-007X
- [PX] FOR THE ARUNDIC ACID (ONO-2506) STROKE STUDY GROUP ET AL: "Safety and tolerability of arundic acid in acute ischemic stroke", JOURNAL OF NEUROLOGICAL SCIENCES, ELSEVIER SCIENTIFIC PUBLISHING CO, AMSTERDAM, NL, vol. 251, no. 1-2, 21 December 2006 (2006-12-21), pages 50 - 56, XP025190710, ISSN: 0022-510X, [retrieved on 20061221]
- See references of WO 2005032537A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005032537 A1 20050414; EP 1667672 A1 20060614; EP 1667672 A4 20100210; JP 2007507490 A 20070329; JP 2012046543 A 20120308; JP 5485497 B2 20140507
DOCDB simple family (application)
JP 2004014893 W 20041001; EP 04773691 A 20041001; JP 2006531234 A 20041001; JP 2011256936 A 20111125