EP 1668133 A1 20060614 - COILED-COIL FUSION PROTEINS COMPRISING CELL RECEPTOR DOMAINS
Title (en)
COILED-COIL FUSION PROTEINS COMPRISING CELL RECEPTOR DOMAINS
Title (de)
ZELLREZEPTORDOMÄNEN UMFASSENDE COILED-COIL-FUSIONSPROTEINE
Title (fr)
PROTEINE HYBRIDE BISPIRALEE AVEC DOMAINES DE RECEPTEURS CELLULAIRES
Publication
Application
Priority
- CA 2004001616 W 20040902
- US 50085503 P 20030905
Abstract (en)
[origin: WO2005024035A1] Fusion proteins and coiled-coil induced dimers prepared from both the ectodomains and the kinase domains are disclosed. The receptor domains when presented in the form of a homodimer or heterodimer by virtue of the coiled-coil tag have enhanced ligand binding activity or enhanced kinase activity. The kinetics of binding and the antagonistic potencies of the ectodomain dimers, and their use to alter or inhibit signaling is described. Application of the ectodomain and kinase domain dimers in assays for selecting compounds capable of inhibiting ligand binding and kinase activity, respectively, is described.
IPC 1-7
IPC 8 full level
C07K 14/71 (2006.01); C12N 15/62 (2006.01); A61K 38/00 (2006.01); G01N 33/53 (2006.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 11/00 (2017.12); A61P 13/12 (2017.12); A61P 19/04 (2017.12); A61P 35/04 (2017.12); A61P 43/00 (2017.12); C07K 14/71 (2013.01); C12N 15/62 (2013.01); A61K 38/00 (2013.01); C07K 2319/73 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005024035 A1 20050317; AU 2004270774 A1 20050317; CA 2536936 A1 20050317; EP 1668133 A1 20060614; EP 1668133 A4 20070829; JP 2007503820 A 20070301
DOCDB simple family (application)
CA 2004001616 W 20040902; AU 2004270774 A 20040902; CA 2536936 A 20040902; EP 04761779 A 20040902; JP 2006525014 A 20040902