EP 1668133 A4 20070829 - COILED-COIL FUSION PROTEINS COMPRISING CELL RECEPTOR DOMAINS
Title (en)
COILED-COIL FUSION PROTEINS COMPRISING CELL RECEPTOR DOMAINS
Title (de)
ZELLREZEPTORDOMÄNEN UMFASSENDE COILED-COIL-FUSIONSPROTEINE
Title (fr)
PROTEINE HYBRIDE BISPIRALEE AVEC DOMAINES DE RECEPTEURS CELLULAIRES
Publication
Application
Priority
- CA 2004001616 W 20040902
- US 50085503 P 20030905
Abstract (en)
[origin: WO2005024035A1] Fusion proteins and coiled-coil induced dimers prepared from both the ectodomains and the kinase domains are disclosed. The receptor domains when presented in the form of a homodimer or heterodimer by virtue of the coiled-coil tag have enhanced ligand binding activity or enhanced kinase activity. The kinetics of binding and the antagonistic potencies of the ectodomain dimers, and their use to alter or inhibit signaling is described. Application of the ectodomain and kinase domain dimers in assays for selecting compounds capable of inhibiting ligand binding and kinase activity, respectively, is described.
IPC 8 full level
C12N 15/62 (2006.01); C07K 14/71 (2006.01); A61K 38/00 (2006.01); G01N 33/53 (2006.01)
CPC (source: EP)
A61P 1/16 (2017.12); A61P 11/00 (2017.12); A61P 13/12 (2017.12); A61P 19/04 (2017.12); A61P 35/04 (2017.12); A61P 43/00 (2017.12); C07K 14/71 (2013.01); C12N 15/62 (2013.01); A61K 38/00 (2013.01); C07K 2319/73 (2013.01)
Citation (search report)
- [A] WO 9712988 A1 19970410 - PENCE INC [CA], et al
- [XY] DE CRESCENZO G ET AL: "Transforming Growth Factor-beta (TGF-beta) Binding to the Extracellular Domain of the Type II TGF-beta Receptor: Receptor Capture on a Biosensor Surface Using a New Coiled-coil Capture System Demonstrates that Avidity Contributes Significantly to High Affinity Binding", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 328, no. 5, 16 May 2003 (2003-05-16), pages 1173 - 1183, XP004454244, ISSN: 0022-2836
- [Y] DE CRESCENZO GREGORY ET AL: "Real-time monitoring of the interactions of two-stranded de novo designed coiled-coils: Effect of chain length on the kinetic and thermodynamic constants of binding.", BIOCHEMISTRY, vol. 42, no. 6, 18 February 2003 (2003-02-18), pages 1754 - 1763, XP008075446, ISSN: 0006-2960
- [A] ANDERS ROBERT A ET AL: "Chimeric granulocyte/macrophage colony-stimulating factor/transforming growth factor-beta (TGF-beta) receptors define a model system for investigating the role of homomeric and heteromeric receptors in TGF-beta signaling", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 36, 1996, pages 21758 - 21766, XP002432036, ISSN: 0021-9258
- [A] HAYS JOHN L ET AL: "Oligomerization-induced modulation of TPR-MET tyrosine kinase activity.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 30, 25 July 2003 (2003-07-25), pages 27456 - 27463, XP002432037, ISSN: 0021-9258
- [XY] BEHNCKEN STUART N ET AL: "Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 22, 2 June 2000 (2000-06-02), pages 17000 - 17007, XP002432034, ISSN: 0021-9258
- [XY] COCHRAN ANDREA G ET AL: "Imitation of Escherichia coli aspartate receptor signaling in engineered dimers of the cytoplasmic domain", SCIENCE (WASHINGTON D C), vol. 271, no. 5252, 1996, pages 1113 - 1116, XP002432035, ISSN: 0036-8075
- See references of WO 2005024035A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005024035 A1 20050317; AU 2004270774 A1 20050317; CA 2536936 A1 20050317; EP 1668133 A1 20060614; EP 1668133 A4 20070829; JP 2007503820 A 20070301
DOCDB simple family (application)
CA 2004001616 W 20040902; AU 2004270774 A 20040902; CA 2536936 A 20040902; EP 04761779 A 20040902; JP 2006525014 A 20040902