EP 1668369 A4 20091021 - EPITOPE PROTECTION ASSAY AND METHOD FOR DETECTING PROTEIN CONFORMATIONS
Title (en)
EPITOPE PROTECTION ASSAY AND METHOD FOR DETECTING PROTEIN CONFORMATIONS
Title (de)
EPITOPSCHUTZTEST UND VERFAHREN ZUM NACHWEIS VON PROTEINKONFORMATIONEN
Title (fr)
DOSAGE DE PROTECTION D'EPITOPE ET PROCEDE DE DETECTION DE CONFORMATIONS PROTEIQUES
Publication
Application
Priority
- CA 2004001503 W 20040820
- US 49638103 P 20030820
- CA 2437675 A 20030820
- US 49736203 P 20030821
- CA 2437999 A 20030821
Abstract (en)
[origin: WO2005019828A1] The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion infections. The methods of the invention first block accessible polypeptide target epitope with a blocking agent. After denaturation of the polypeptide, a detecting agent is used to detect protein with target epitope that was inaccessible during contact with the blocking agent.
IPC 8 full level
G01N 33/53 (2006.01); G01N 33/569 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
A61P 25/00 (2017.12 - EP); C07K 16/18 (2013.01 - EP US); C07K 16/40 (2013.01 - US); G01N 33/58 (2013.01 - US); G01N 33/581 (2013.01 - US); G01N 33/68 (2013.01 - EP US); G01N 33/6845 (2013.01 - EP US); G01N 33/6896 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C07K 2317/31 (2013.01 - US); C07K 2317/34 (2013.01 - US); C07K 2317/54 (2013.01 - US); C07K 2317/55 (2013.01 - US); C07K 2317/622 (2013.01 - US); C07K 2317/624 (2013.01 - US); C07K 2317/626 (2013.01 - US); G01N 2333/90283 (2013.01 - US); G01N 2800/28 (2013.01 - US); G01N 2800/2828 (2013.01 - EP US)
Citation (search report)
- [XY] WO 0022438 A1 20000420 - UNIV CALIFORNIA [US], et al
- [X] WO 0078344 A1 20001228 - CAPRION PHARMACEUTICALS INC [CA], et al
- [XY] LEHTO M T ET AL: "PEROXYNITRITE As A PROBE FOR THE STRUCTURE OF NORMAL AND MISFOLDED PRION PROTEIN, PrP!C", ABSTRACTS OF THE ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE, SOCIETY FOR NEUROSCIENCE, WASHINGTON, DC, US, vol. 32, 2 November 2002 (2002-11-02), pages Abstract692.9, XP001538981, ISSN: 0190-5295
- [X] BRUIJN L I ET AL: "ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions", NEURON, vol. 18, no. 2, 1997, pages 327 - 338, XP002542629, ISSN: 0896-6273
- See references of WO 2005019828A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005019828 A1 20050303; AU 2004266324 A1 20050303; AU 2004266324 B2 20110106; AU 2004266324 B8 20110428; EP 1668369 A1 20060614; EP 1668369 A4 20091021; EP 1668369 B1 20160106; JP 2007502966 A 20070215; JP 2010265290 A 20101125; JP 4668191 B2 20110413; JP 5357111 B2 20131204; US 2006246517 A1 20061102; US 2007003977 A1 20070104; US 2009098151 A1 20090416; US 2011124018 A1 20110526; US 2011135673 A1 20110609; US 2012077212 A1 20120329; US 2014335538 A1 20141113; US 2017192020 A1 20170706; US 7439324 B2 20081021; US 7763710 B2 20100727; US 8075891 B2 20111213; US 8828389 B2 20140909; US 9523697 B2 20161220; US 9625476 B2 20170418
DOCDB simple family (application)
CA 2004001503 W 20040820; AU 2004266324 A 20040820; EP 04761667 A 20040820; JP 2006523496 A 20040820; JP 2010153006 A 20100705; US 201113313869 A 20111207; US 201414448584 A 20140731; US 201715452356 A 20170307; US 23673108 A 20080924; US 36760906 A 20060303; US 56872906 A 20060713; US 79239410 A 20100602; US 91060010 A 20101022