EP 1671654 A2 20060621 - Conjugates of hydroxyalkylstarch and an active agent

Title (en)

Conjugates of hydroxyalkylstarch and an active agent

Title (de)

Hydroxyalkylstärke-Wirkstoff-Konjugate

Title (fr)

Conjugués de l'hydroxyalkyl-amidon et d'une substance active.

Publication

EP 1671654 A2 20060621 (DE)

Application

EP 06002435 A 20020315

Priority

EP 02742858 A 20020315
DE 10112825 A 20010316

Abstract (en)

Production of a covalent conjugate (I) of hydroxyethyl starch (HES) and an active agent (A), comprises reacting HES and (A) in a reaction medium. Production of a covalent conjugate (I) of hydroxyethyl starch (HES) and an active agent (A), comprises reacting HES and (A) in a reaction medium, the reaction medium consists of water or a water-organic solvent mixture containing at least 10 weight. % water. An independent claim is included for (I).

Abstract (de)

Die vorliegende Erfindung betrifft Verbindungen, die ein Konjugat aus Hydroxalkystärke (HAS) und einem Wirkstoff umfassen, wobei die Hydroxalkystärke entweder unmittelbar oder über einen Linker kovalent an den Wirkstoff gebunden ist. Die Erfindung betrifft ferner Verfahren zur Herstellung eines kovalenten HAS-Wirkstoff-Konjugates, bei denen man HAS und einen Wirkstoff in einem Reaktionsmedium miteinander umsetzt, dadurch gekennzeichnet, dass das Reaktionsmedium Wasser oder ein Gemisch von Wasser mit organischen Lösungsmittel, welches mindestens 10 Gew.-% Wasser umfasst, ist.

IPC 8 full level

A61K 47/48 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 47/36 (2006.01); A61K 48/00 (2006.01); A61P 3/02 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 5/00 (2006.01); A61P 5/44 (2006.01); A61P 5/50 (2006.01); A61P 7/00 (2006.01); A61P 7/06 (2006.01); A61P 9/06 (2006.01); A61P 11/06 (2006.01); A61P 13/00 (2006.01); A61P 13/12 (2006.01); A61P 23/00 (2006.01); A61P 23/02 (2006.01); A61P 25/24 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 31/04 (2006.01); A61P 31/06 (2006.01); A61P 31/10 (2006.01); A61P 31/12 (2006.01); A61P 33/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 35/04 (2006.01); A61P 37/04 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01)

CPC (source: EP KR US)

A61K 47/50 (2017.08 - KR); A61K 47/61 (2017.08 - EP US); A61K 47/643 (2017.08 - EP US); A61P 3/02 (2018.01 - EP); A61P 3/04 (2018.01 - EP); A61P 3/10 (2018.01 - EP); A61P 5/00 (2018.01 - EP); A61P 5/44 (2018.01 - EP); A61P 5/50 (2018.01 - EP); A61P 7/00 (2018.01 - EP); A61P 7/06 (2018.01 - EP); A61P 9/06 (2018.01 - EP); A61P 11/06 (2018.01 - EP); A61P 13/00 (2018.01 - EP); A61P 13/12 (2018.01 - EP); A61P 23/00 (2018.01 - EP); A61P 23/02 (2018.01 - EP); A61P 25/24 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 31/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 31/06 (2018.01 - EP); A61P 31/10 (2018.01 - EP); A61P 31/12 (2018.01 - EP); A61P 33/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 35/02 (2018.01 - EP); A61P 35/04 (2018.01 - EP); A61P 37/04 (2018.01 - EP); A61P 37/08 (2018.01 - EP); A61P 43/00 (2018.01 - EP)

Citation (applicant)

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Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

DE 10112825 A1 20021002; AT E529134 T1 20111115; BG 108274 A 20040831; BR 0208126 A 20040302; CA 2441442 A1 20021017; CN 101597337 A 20091209; CN 101597337 B 20110907; CN 1498115 A 20040519; CZ 20032430 A3 20031112; EP 1372735 A2 20040102; EP 1372735 B1 20111019; EP 1671654 A2 20060621; EP 1671654 A3 20080326; ES 2371865 T3 20120110; HU P0303511 A2 20040128; IS 6953 A 20030915; JP 2004525170 A 20040819; KR 20030084998 A 20031101; MX PA03008218 A 20040310; NO 20034095 D0 20030915; NO 20034095 L 20031104; NZ 528251 A 20041224; PL 366456 A1 20050207; RU 2003130464 A 20050410; US 2005063943 A1 20050324; US 2006188472 A1 20060824; US 7816516 B2 20101019; WO 02080979 A2 20021017; WO 02080979 A3 20030912; YU 72203 A 20060525; ZA 200306363 B 20040713

DOCDB simple family (application)

DE 10112825 A 20010316; AT 02742858 T 20020315; BG 10827403 A 20031015; BR 0208126 A 20020315; CA 2441442 A 20020315; CN 02806722 A 20020315; CN 200910203522 A 20020315; CZ 20032430 A 20020315; EP 0202928 W 20020315; EP 02742858 A 20020315; EP 06002435 A 20020315; ES 02742858 T 20020315; HU P0303511 A 20020315; IS 6953 A 20030915; JP 2002579017 A 20020315; KR 20037012061 A 20030916; MX PA03008218 A 20020315; NO 20034095 A 20030915; NZ 52825102 A 20020315; PL 36645602 A 20020315; RU 2003130464 A 20020315; US 35171406 A 20060210; US 47200204 A 20040922; YU P72203 A 20020315; ZA 200306363 A 20030815