EP 1675948 A2 20060705 - RNA INTERFERENCE MEDIATED TREATMENT OF PARKINSON DISEASE USING SHORT INTERERING NUCLEIC ACID (siNA)
Title (en)
RNA INTERFERENCE MEDIATED TREATMENT OF PARKINSON DISEASE USING SHORT INTERERING NUCLEIC ACID (siNA)
Title (de)
RNA-INTERFERENZ-VERMITTELTE BEHANDLUNG VON MORBUS PARKINSON UNTER VERWENDUNG VON SINA (SHORT INTERFERING NUCLEIC ACID)
Title (fr)
TRAITEMENT MEDIE PAR INTERFERENCE ARN DE LA MALADIE DE PARKINSON AU MOYEN D'UN PETIT ACIDE NUCLEIQUE INTERFERENT (SINA)
Publication
Application
Priority
- US 2004017630 W 20040603
- US 69305903 A 20031023
- US 69831103 A 20031031
- US 72044803 A 20031124
- US 72778003 A 20031203
- US 75780304 A 20040114
- US 54348004 P 20040210
- US 78044704 A 20040213
- US 82696604 A 20040416
- US 2004013456 W 20040430
- US 2004016390 W 20040524
Abstract (en)
[origin: WO2005045034A2] The present invention concerns methods and reagents useful in modulating Parkinson genes, for example, PARK1 (SNCA), PARK2, PARK7, and/or PARK5 gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against SNCA gene expression and/or activity. The small nucleic acid molecules are useful in the diagnosis and treatment of Parkinson Disease (PD), and any other disease or condition that responds to modulation of PARK1 (SNCA), PARK2, PARK7, and/or PARK5 expression or activity.
IPC 1-7
C12N 15/11; C12P 19/34; C07H 21/02; C07H 21/04; A01N 43/04; A61K 31/713
IPC 8 full level
C12N 15/113 (2010.01)
CPC (source: EP)
A61K 49/0008 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/317 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/332 (2013.01)
Citation (search report)
See references of WO 2005045034A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005045034 A2 20050519; WO 2005045034 A3 20050811; EP 1675948 A2 20060705
DOCDB simple family (application)
US 2004017630 W 20040603; EP 04754277 A 20040603