EP 1675949 A2 20060705 - RNA INTERFERENCE MEDIATED INHIBITION OF NOGO AND NOGO RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
Title (en)
RNA INTERFERENCE MEDIATED INHIBITION OF NOGO AND NOGO RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
Title (de)
RNA-INTERFERENZ-VERMITTELTE HEMMUNG DER NOGO- UND NOGO-REZEPTOR-GENEXPRESSION UNTER VERWENDUNG VON SINA (SHORT INTERFERING NUCLEIC ACID)
Title (fr)
INHIBITION MEDIEE PAR INTERFERENCE ARN DE L'EXPRESSION GENIQUE DE NOGO ET DU RECEPTEUR NOGO AU MOYEN D'UN PETIT ACIDE NUCLEIQUE INTERFERENT (siNA)
Publication
Application
Priority
- US 2004026930 W 20040820
- US 69305903 A 20031023
- US 72044803 A 20031124
- US 72778003 A 20031203
- US 75780304 A 20040114
- US 54348004 P 20040210
- US 78044704 A 20040213
- US 82696604 A 20040416
- US 2004013456 W 20040430
- US 2004016390 W 20040524
Abstract (en)
[origin: WO2005040379A2] This invention relates to compounds, compositions, and methods useful for modulating RAS, e.g. K-RAS, H-RAS, and/or N-RAS gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of RAS, e.g. K-RAS, H-RAS, and/or N-RAS gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of RAS genes, such as K-RAS, H-RAS, and/or N-RAS.
IPC 1-7
IPC 8 full level
C12N 5/02 (2006.01); C12N 5/22 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/87 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 49/0008 (2013.01); A61P 3/00 (2017.12); A61P 3/06 (2017.12); A61P 3/10 (2017.12); A61P 9/00 (2017.12); A61P 9/04 (2017.12); A61P 9/06 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 21/00 (2017.12); A61P 21/04 (2017.12); A61P 25/00 (2017.12); A61P 25/08 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/18 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 27/02 (2017.12); A61P 29/00 (2017.12); A61P 31/00 (2017.12); A61P 31/04 (2017.12); A61P 31/10 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); C12N 15/111 (2013.01); C12N 15/1135 (2013.01); C12N 15/87 (2013.01); C12N 2310/111 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/317 (2013.01); C12N 2310/318 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/332 (2013.01); C12N 2310/346 (2013.01); C12N 2310/53 (2013.01); C12N 2320/32 (2013.01); C12N 2330/30 (2013.01)
Citation (search report)
See references of WO 2005045035A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005040379 A2 20050506; WO 2005040379 A3 20060302; CA 2542835 A1 20050519; CA 2543013 A1 20050519; EP 1675949 A2 20060705; EP 1675953 A2 20060705; EP 1682661 A2 20060726; JP 2007522793 A 20070816; JP 2008506351 A 20080306; WO 2005044981 A2 20050519; WO 2005044981 A3 20050922; WO 2005045035 A2 20050519; WO 2005045035 A3 20051208
DOCDB simple family (application)
US 2004027333 W 20040820; CA 2542835 A 20040820; CA 2543013 A 20040820; EP 04781588 A 20040820; EP 04781982 A 20040820; EP 04816819 A 20040820; JP 2006536609 A 20040820; JP 2006536613 A 20040820; US 2004026930 W 20040820; US 2004027403 W 20040820