Global Patent Index - EP 1680136 A1

EP 1680136 A1 20060719 - PEPTIDES HAVING, FOR EXAMPLE, AN ANTIANGIOGENIC ACTIVITY AND APPLICATIONS THEREOF IN THERAPEUTICS

Title (en)

PEPTIDES HAVING, FOR EXAMPLE, AN ANTIANGIOGENIC ACTIVITY AND APPLICATIONS THEREOF IN THERAPEUTICS

Title (de)

PEPTIDE BEISPIELSWEISE MIT ANTIANGIOGENER WIRKUNG UND IHRE ANWENDUNGEN IN THERAPEUTIKA

Title (fr)

PEPTIDES POSSEDANT NOTAMMENT UNE ACTIVITE ANTI-ANGIOGENIQUE ET LEURS APPLICATIONS EN THERAPEUTIQUE

Publication

EP 1680136 A1 20060719 (FR)

Application

EP 04787446 A 20040924

Priority

  • FR 2004002422 W 20040924
  • FR 0311270 A 20030925

Abstract (en)

[origin: WO2005030238A1] The invention relates to cyclised peptides corresponding to sequence SEQ ID N DEG 1: X1X2RGDX3FGX4X5LLFIHFX6IGSX7HSX8IX9, wherein: the letters without any numerical index correspond to amino acids defined by the single-letter international code; X1 is G or GG having an amino-terminal end which may or may not be free; X2 is either a C, in which case X2 = X4, the two Cs being connected by a disulphide bridge, or X2 is capable of forming a lactam bridge with X4, either X2 or X4 being an amino acid bearing an acid group, such as A or D, and the other bearing an amino function such as Q, N; X3 is either an M pattern or a norleucine pattern; X5 is one or several di-, tri-, or tetra-peptide patterns comprising G or a combination of G and S, or X5 is a C pattern having a side-chain which serves as a covalent linkage point with a 3-nitro-2-pyridinesulphenyl group which is located at the N-terminal end of the next amino acid (L); X6 is either an R pattern or a K pattern; X7 is either an R pattern or a K pattern; X8 is either an R pattern or a K pattern; and X9 is an aliphatic amino acid (such as G or A) having an amide C-terminal end. The inventive peptides can be used as active ingredients in medicaments, for example, for the treatment of pathologies linked to hypervascularisation.

IPC 1-7

A61K 38/00; C07K 14/00; A61P 35/00

IPC 8 full level

A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61P 9/00 (2006.01); A61P 35/00 (2006.01); C07K 14/00 (2006.01); C07K 14/46 (2006.01); C07K 14/78 (2006.01)

CPC (source: EP US)

A61P 9/00 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 35/00 (2018.01 - EP); C07K 14/001 (2013.01 - EP US); C07K 14/78 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

FR 2860236 A1 20050401; FR 2860236 B1 20060106; EP 1680136 A1 20060719; IL 174547 D0 20060801; JP 2007506713 A 20070322; US 2008171697 A1 20080717; WO 2005030238 A1 20050407

DOCDB simple family (application)

FR 0311270 A 20030925; EP 04787446 A 20040924; FR 2004002422 W 20040924; IL 17454706 A 20060323; JP 2006527447 A 20040924; US 57357604 A 20040924