EP 1680423 A1 20060719 - AZABENZODIAZEPINES AS PHOSPHODIESTERASE-4 INHIBITORS
Title (en)
AZABENZODIAZEPINES AS PHOSPHODIESTERASE-4 INHIBITORS
Title (de)
AZABENZODIAZEPINE ALS PHOSPHODIESTERASE-4-INHIBITOREN
Title (fr)
AZABENZODIAZEPINES UTILES COMME INHIBITEURS DE PDE4
Publication
Application
Priority
- IB 2004003406 W 20041018
- EP 03292660 A 20031024
- EP 04769665 A 20041018
Abstract (en)
[origin: EP1526135A1] Compounds of formula (I): characterized in that:R<sub>1</sub> represents a group selected from hydrogen atom, methyl, methoxy, hydroxy, amino, dimethylamino, acetamido, pyrrolidin-1-yl, and hydroxymethyl;R<sub>2</sub> represent a group selected from phenyl, pyridyl, pyrimidyl, quinolyl, isoquinolyl, indolyl, pyrolyl, [1,2,3]-triazolyl, benzo[c]isoxazolyl, thienyl, pyrazolyl, isothiazolyl, imidazolyl, benzofuranyl, pyrazolo[5,1-c][1,2,4]triazyl each of these groups being optionally substituted from 1 to 3 groups, identical or different independently of each other, selected from halogen, trifluoromethyl, (C<sub>1</sub>-C<sub>4</sub>)alkyl, (C<sub>1</sub>-C<sub>4</sub>)alkoxy, hydroxy, amino, acetamido, tert-butyloxycarbonylamino, cycloalkylcarbonylamino, sulfonamide, nitro, acetylmethoxy, cyclopentyloxy; optionally, their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid or base,and their use as active ingredient in pharmaceutical composition useful for treating diseases involving therapy by inhibition of PDE4.
IPC 1-7
IPC 8 full level
A61K 31/55 (2006.01); C07D 471/16 (2006.01)
CPC (source: EP)
A61P 1/04 (2017.12); A61P 9/04 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 17/00 (2017.12); A61P 17/02 (2017.12); A61P 17/06 (2017.12); A61P 19/02 (2017.12); A61P 19/04 (2017.12); A61P 19/10 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); A61P 31/18 (2017.12); A61P 35/00 (2017.12); A61P 37/06 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C07D 471/16 (2013.01)
Citation (search report)
See references of WO 2005040168A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
EP 1526135 A1 20050427; BR PI0415570 A 20070102; CA 2542720 A1 20050506; EP 1680423 A1 20060719; JP 2007509127 A 20070412; MX PA06004486 A 20060620; WO 2005040168 A1 20050506
DOCDB simple family (application)
EP 03292660 A 20031024; BR PI0415570 A 20041018; CA 2542720 A 20041018; EP 04769665 A 20041018; IB 2004003406 W 20041018; JP 2006536201 A 20041018; MX PA06004486 A 20041018