EP 1682540 A1 20060726 - AZOLIDINECARBONITRILES AND THEIR USE AS DPP-IV INHIBITORS
Title (en)
AZOLIDINECARBONITRILES AND THEIR USE AS DPP-IV INHIBITORS
Title (de)
AZOLIDINCARBONITRILE UND IHRE VERWENDUNG ALS DPP-IV HEMMER
Title (fr)
AZOLIDINECARBONITRILES ET LEUR APPLICATION COMME INHIBITEURS DE DPP-IV
Publication
Application
Priority
IB 0304377 W 20031006
Abstract (en)
[origin: WO2005033106A1] The invention discloses a novel heterocyclic compounds that falls within f the ambit of general formula (I), its stereoisomers, pharmaceutically acceptable salts or solvates wherein X, n,k,z, R1, R2, R3, R4, R5 and R6 are as defined in the specification that are useful in (i) normalizing elevated blood pglucose levels in diabetes, (ii) treating disorders related to glucose intolerance and (iii) for scavenging free radicals of mammals. The invention also discloses pharmaceutically acceptable composition comprising these compounds, method for preparation of the compounds as defined bove and method of treating mammals including human beings by administering an effective amount of said compounds to a subject in need thereof. The invention further discloses use of these compounds in the manufacture of a medicament useful for treatment of different disease conditions as stated above.
IPC 8 full level
C07D 417/14 (2006.01); A61K 31/421 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/497 (2006.01); A61P 3/10 (2006.01); C07D 263/04 (2006.01); C07D 401/14 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP)
A61P 1/04 (2017.12); A61P 1/12 (2017.12); A61P 1/16 (2017.12); A61P 3/00 (2017.12); A61P 3/04 (2017.12); A61P 3/10 (2017.12); A61P 5/06 (2017.12); A61P 5/14 (2017.12); A61P 5/16 (2017.12); A61P 5/38 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 11/06 (2017.12); A61P 13/12 (2017.12); A61P 25/00 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); A61P 27/02 (2017.12); A61P 27/12 (2017.12); A61P 29/00 (2017.12); A61P 31/18 (2017.12); A61P 35/00 (2017.12); A61P 39/06 (2017.12); A61P 43/00 (2017.12); C07D 263/04 (2013.01); C07D 401/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01)
Citation (search report)
See references of WO 2005033106A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005033106 A1 20050414; AU 2003269307 A1 20050421; BR 0318533 A 20060912; CA 2534634 A1 20050414; CN 1839131 A 20060927; EP 1682540 A1 20060726; JP 2007516154 A 20070621; PL 380189 A3 20070108
DOCDB simple family (application)
IB 0304377 W 20031006; AU 2003269307 A 20031006; BR 0318533 A 20031006; CA 2534634 A 20031006; CN 200380110465 A 20031006; EP 03751086 A 20031006; JP 2005509281 A 20031006; PL 38018903 A 20031006