Global Patent Index - EP 1685094 A4

EP 1685094 A4 20070822 - ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES

Title (en)

ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES

Title (de)

MIT ACYLHARNSTOFF VERBUNDENE UND MIT SULFONYLHARNSTOFF VERBUNDENE HYDROXAMATE

Title (fr)

HYDROXAMATES CONNECTES A L'ACYLUREE ET A LA SULFONYLUREE

Publication

EP 1685094 A4 20070822 (EN)

Application

EP 04775672 A 20041026

Priority

  • SG 2004000353 W 20041026
  • US 51401303 P 20031027

Abstract (en)

[origin: WO2005040101A1] The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to acylurea/sulfonylurea containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities.

IPC 8 full level

C07C 275/50 (2006.01); C07C 275/54 (2006.01); C07C 311/58 (2006.01); C07C 311/60 (2006.01); C07C 335/26 (2006.01); C07D 207/27 (2006.01); C07D 209/16 (2006.01); C07D 213/40 (2006.01); C07D 233/54 (2006.01); C07D 233/61 (2006.01); C07D 235/14 (2006.01); C07D 285/06 (2006.01); C07D 295/13 (2006.01); C07D 295/215 (2006.01); C07D 307/14 (2006.01); C07D 307/85 (2006.01); C07D 333/20 (2006.01); C07D 333/38 (2006.01); C07D 207/26 (2006.01); C07D 235/10 (2006.01)

CPC (source: EP)

A61P 1/04 (2017.12); A61P 1/16 (2017.12); A61P 3/00 (2017.12); A61P 3/10 (2017.12); A61P 7/00 (2017.12); A61P 7/06 (2017.12); A61P 9/00 (2017.12); A61P 9/04 (2017.12); A61P 9/08 (2017.12); A61P 9/10 (2017.12); A61P 11/06 (2017.12); A61P 13/08 (2017.12); A61P 13/10 (2017.12); A61P 17/06 (2017.12); A61P 19/02 (2017.12); A61P 21/00 (2017.12); A61P 21/04 (2017.12); A61P 25/00 (2017.12); A61P 25/02 (2017.12); A61P 25/08 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/18 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 27/02 (2017.12); A61P 27/06 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); A61P 31/10 (2017.12); A61P 31/12 (2017.12); A61P 31/22 (2017.12); A61P 33/02 (2017.12); A61P 33/06 (2017.12); A61P 35/00 (2017.12); A61P 35/02 (2017.12); A61P 37/02 (2017.12); A61P 37/06 (2017.12); A61P 43/00 (2017.12); C07C 275/50 (2013.01); C07C 275/54 (2013.01); C07C 311/58 (2013.01); C07C 311/60 (2013.01); C07C 335/26 (2013.01); C07D 207/27 (2013.01); C07D 209/16 (2013.01); C07D 213/40 (2013.01); C07D 233/64 (2013.01); C07D 235/14 (2013.01); C07D 285/06 (2013.01); C07D 295/13 (2013.01); C07D 295/215 (2013.01); C07D 307/14 (2013.01); C07D 307/85 (2013.01); C07D 333/20 (2013.01); C07D 333/38 (2013.01)

Citation (search report)

  • [XA] ILIES, MONICA ET AL: "Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties", BIOORGANIC & MEDICINAL CHEMISTRY , 11(10), 2227-2239 CODEN: BMECEP; ISSN: 0968-0896, 2003, XP002442172
  • [XA] SCOZZAFAVA, ANDREA ET AL: "Protease Inhibitors: Synthesis of Potent Bacterial Collagenase and Matrix Metalloproteinase Inhibitors Incorporating N-4-Nitrobenzylsulfonylglycine Hydroxamate Moieties", JOURNAL OF MEDICINAL CHEMISTRY , 43(9), 1858-1865 CODEN: JMCMAR; ISSN: 0022-2623, 2000, XP000986258
  • [XA] SCOZZAFAVA, A. ET AL: "Protease inhibitors. Part 12. Synthesis of potent matrix metalloproteinase and bacterial collagenase inhibitors incorporating sulfonylated N-4-nitrobenzyl-.beta.-alanine hydroxamate moieties", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES , 11(1), 69-79 CODEN: EPSCED; ISSN: 0928-0987, 2000, XP000971120
  • [XA] SCOZZAFAVA, A. ET AL: "Protease inhibitors. Part 8. Synthesis of potent Clostridium histolyticum collagenase inhibitors incorporating sulfonylated L- alanine hydroxamate moieties", BIOORGANIC & MEDICINAL CHEMISTRY , 8(3), 637-645 CODEN: BMECEP; ISSN: 0968-0896, 2000, XP002975845
  • [XA] SCOZZAFAVA, ANDREA ET AL: "Protease inhibitors: synthesis of Clostridium histolyticum collagenase inhibitors incorporating sulfonyl-L- alanine hydroxamate moieties", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 10(5), 499-502 CODEN: BMCLE8; ISSN: 0960-894X, 2000, XP004202447
  • [XA] CLARE, BRIAN W. ET AL: "Protease Inhibitors: Synthesis of a Series of Bacterial Collagenase Inhibitors of the Sulfonyl Amino Acyl Hydroxamate Type", JOURNAL OF MEDICINAL CHEMISTRY , 44(13), 2253-2258 CODEN: JMCMAR; ISSN: 0022-2623, 2001, XP002442173
  • See references of WO 2005040101A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2005040101 A1 20050506; AR 046920 A1 20060104; AU 2004284030 A1 20050506; CA 2543570 A1 20050506; EP 1685094 A1 20060802; EP 1685094 A4 20070822; JP 2007509930 A 20070419; MX PA06004735 A 20061214; TW 200530166 A 20050916

DOCDB simple family (application)

SG 2004000353 W 20041026; AR P040103893 A 20041026; AU 2004284030 A 20041026; CA 2543570 A 20041026; EP 04775672 A 20041026; JP 2006537946 A 20041026; MX PA06004735 A 20041026; TW 93132561 A 20041026