EP 1685410 A1 20060802 - DIAGNOSTIC AND THERAPEUTIC USE OF THE HUMAN SGPL1 GENE AND PROTEIN FOR NEURODEGENERATIVE DISEASES
Title (en)
DIAGNOSTIC AND THERAPEUTIC USE OF THE HUMAN SGPL1 GENE AND PROTEIN FOR NEURODEGENERATIVE DISEASES
Title (de)
DIAGNOSTISCHE UND THERAPEUTISCHE VERWENDUNG DES MENSCHLICHEN SGPL1-GENS UND PROTEIN BEI NEURODEGENERATIVEN ERKRANKUNGEN
Title (fr)
UTILISATION DIAGNOSTIQUE ET THERAPEUTIQUE DU GENE HUMAIN SGPL1 ET D'UNE PROTEINE CONTRE LES MALADIES NEURODEGENERATIVES
Publication
Application
Priority
- EP 2004013111 W 20041118
- US 52309703 P 20031119
Abstract (en)
[origin: WO2005050222A1] The present invention discloses the differential expression of a gene coding for SGPL1 in specific brain regions of Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the SGPL1 gene and its corresponding gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
IPC 8 full level
C12N 9/88 (2006.01); C12Q 1/68 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
C12N 9/88 (2013.01 - EP US); C12Q 1/6883 (2013.01 - EP US); G01N 33/6896 (2013.01 - EP US); A01K 2217/075 (2013.01 - EP US); A01K 2267/0312 (2013.01 - EP US); C12Q 2600/112 (2013.01 - EP US); C12Q 2600/158 (2013.01 - EP US); G01N 2333/988 (2013.01 - EP US); G01N 2500/04 (2013.01 - EP US); G01N 2800/2821 (2013.01 - EP US)
Citation (search report)
See references of WO 2005050222A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005050222 A1 20050602; EP 1685410 A1 20060802; US 2007162983 A1 20070712
DOCDB simple family (application)
EP 2004013111 W 20041118; EP 04818804 A 20041118; US 59593004 A 20041118